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Completed

NCT Number: NCT01059968

Low Energy Availability, Menstrual Irregularity, and Low Bone Mass

This study examines the role of energy availability on menstrual function and bone mass in female adolescent endurance athletes. Specific evaluations include dietary intake, exercise energy expenditure, training schedules, menstrual function and bone density.

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Key information

Conditions

Bone Density Energy Availability

Age range

15 year–17 year

Sex eligibility

Female

Study type

Observational

Primary location

Marta Van Loan

Davis, California, 95616, United States

About this study

The purpose of this project is to examine the relationships among low energy availability, H-P-A axis, menstrual function and bone density and bone turnover in high school female cross country runners. Our objectives are to: 1)determine energy intake, exercise energy expenditure, and fat-free mass to examine energy availability; 2)in a subset of runners, using double labelled water, estimate total energy expenditure and indirect calorimetry to estimate resting metabolic rate; 3)assess the relationship between energy availability, hormones that regulate bone turnover, markers of bone formation and resorption and bone mineral content and density; 4)identify the relationship between energy availability, hormones that regulate menstrual function and current menstrual status; and 5)determine the energy intake and energy expenditure variables exhibiting the strongest associations with energy availability.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • high school female cross country runners
  • ages 15-17 years
  • 1-5 years experience as cross country runner
  • 25 miles or more/week training

Exclusion criteria

  • medications known to affect bone metabolism
  • pregnancy

Treatment and study plan

Primary outcomes

  1. Bone density

    Time frame: 3 months

Secondary outcomes

  1. Energy availability

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

USDA, Western Human Nutrition Research Center

Fed

Collaborators

  • San Diego State University

Registry information

Official study title

The Role of Low Energy Availability and the H-P-A Axis, Menstrual Irregularity, and Low Bone Mass

Important dates

Study start
2008
Primary completion
2008
Study completion
2009
First posted
Feb 1, 2010
Registry last updated
Jun 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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