Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07715188

Low Dose Radiotherapy for Osteoarthritis

This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Osteoarthitis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States

Loading trial locations.

About this study

To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows.
  • Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
  • Provision of signed and dated informed consent.

Exclusion criteria

  • Unable to reasonably complete study instruments.

Treatment and study plan

Low Dose Radiation Therapy

Radiation

Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.

Primary outcomes

  1. To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF

    Time frame: Within 1 year

    Assess the degree of patient-reported pain prior to and after use of 1-2 courses of LDRT

Secondary outcomes

  1. To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF

    Time frame: at ~ 3 months

    Assess the degree of patient-reported pain prior to and after 1 course of LDRT

  2. To measure change in PROMIS scores

    Time frame: From baseline at 3-month and 1-year follow-up

    Assess the degree of patient-reported global wellness prior to and after use of 1-2 courses of LDRT

  3. To measure change in LEFS scores as measured

    Time frame: From baseline at 3-month and 1-year follow-up

    Assess the degree of patient-reported lower extremity function prior to and after use of 1-2 courses of LDRT

  4. To measure change in UEFI scores as measured

    Time frame: From baseline at 3-month and 1-year follow-up

    Assess the degree of patient-reported upper extremity function prior to and after use of 1-2 courses of LDRT

Study contacts

Contact information is provided by the study sponsor or research team.

Marlowe Estioko, BS, MS

CONTACT

[email protected]

267-343-6483

Sonya George, BS

CONTACT

[email protected]

267-760-7636

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Registry information

Official study title

A Prospective Study of Low Dose Radiotherapy for Osteoarthritis

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Jul 20, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.