Low Dose Human Chorionic Gonadotropin: Influence on the Endometrium

The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. The study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone antagonist protocol for in vitro fertilization, are studied. In addition to the histological findings, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, the investigators want to study the implantation potential.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–36 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

UZ Brussel

Laarbeeklaan 101, Brussels Capital, 1090, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

< 36 years on day of randomisation
FSH < 12 in the early follicular phase
Normal ultrasound scan
BMI between 18 and 29 (both inclusive)
Randomisation at outpatient clinic

Exclusion criteria

Endometriosis ≥ grade 3
PCO syndrome
Poor responder
Endocrine or metabolic abnormalities

Treatment and study plan

human menopausal gonadotropin

Drug

200 IU per day in the late follicular phase

Primary outcomes

number of oocytes

Time frame: 2 weeks after start of the treatment

Sponsors and collaborators

Lead sponsor

Universitair Ziekenhuis Brussel

Other

Registry information

Official study title

Influence of Ovarian Stimulation With 200 IU of hCG, (Administered in the Late Follicular Phase Among ICSI Patients Undergoing a GnRH-antagonist Protocol), on the Endometrium on the Day of Oocyte Pick-up

Important dates

Study start: 2009
Primary completion: 2009
Study completion: 2009
First posted: Sep 14, 2009
Registry last updated: Mar 25, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed