Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.

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Key information

Conditions

Lung Cancer Hemic and Lymphatic Diseases Hodgkin Disease Immune System Diseases Immunoproliferative Disorders Lung Diseases Lung Neoplasms Lymphatic Diseases Lymphoma Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brigham and Women's Hospital, Boston, Massachusetts, United States

About this study

Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

5 years or longer from initial Hodgkin's disease diagnosis
Current age 18 or older
Received mediastinal irradiation and/or alkylating-agent based chemotherapy
Smoking history of 10-pack years or more, or current smoker
Pre-approval from the participant's insurance company for the CT study

Exclusion criteria

Patients with a history of lung cancer
Currently receiving treatment for another cancer diagnosis
Known diagnosis of any metastatic cancer
Pregnant women

Treatment and study plan

chest computed tomography scan

Procedure

Once a year for three years

Other names: CT scan

Primary outcomes

To Prospectively Collect Data on Chest CT Screening for Patients at Increase Lung-cancer Risk After Hodgkin's Disease.

Time frame: 3 years

In this study, patients will under annual low-dose chest CT screening. The total number of lung cancer detected through the screening will be recorded

Sponsors and collaborators

Lead sponsor

Dana-Farber Cancer Institute

Other

Collaborators

Brigham and Women's Hospital

Registry information

Important dates

Study start: 2006
Primary completion: 2010
Study completion: 2019
First posted: Jan 25, 2008
Registry last updated: Jan 21, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed