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Completed

NCT Number: NCT04368325

Low Creatinine Level and Respiratory Failure

Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

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Key information

Conditions

Intensive Care Unit Muscle Weakness Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University hospital centre Osijek

Osijek, 31000, Croatia

About this study

The investigators have found a total of 46 participants with low creatinine levels and compared their outcome data with a group of participants with normal or high creatinine levels (control group, N=61). Low creatinine was defined as values of ≤40 μmol/L. Demographic data, type of admission (medical vs. surgical), hemoglobin values, CRP, and ventilator days were compared. A statistical analysis was performed using chi square and T-test.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion criteria for study group was value of ≤40 µmol/L serume creatinine level during hospitalization in ICU from July 2015 to November 2016.

Exclusion criteria

  • Patients who were younger than 18 years

Treatment and study plan

Serum creatinine levels

Diagnostic Test

Comparison of treatment length using mechanical ventilaton, length of stay in ICU, survival between two groups

Primary outcomes

  1. Length of mechanical ventilation treatment in group with low serume creatinine level

    Time frame: Through study completion, an average of 1 year

    The investigators compared length of mechanical ventilation treatment between group with low serume creatinine level and control group

Secondary outcomes

  1. Length of stay in ICU in group with low serume creatinine level

    Time frame: Through study completion, an average of 1 year

    The investigators compared length of stay in ICU between group with low serume creatinine level and control group

  2. White blood cell values in group with low creatinine level

    Time frame: Through study completion, an average of 1 year

    The investigators compared white blood cell values between group with low creatinine level and control group

  3. Hemoglobine values in group with low creatinine level

    Time frame: Through study completion, an average of 1 year

    The investigators compared hemoglobine values between group with low creatinine level and control group

  4. Number of patients who started nutrition in ICU

    Time frame: Through study completion, an average of 1 year

    The investigators compared number of patients between group with low creatinine level and control group who started nutrition in ICU

  5. Platelets values in group with low creatinine level

    Time frame: Through study completion, an average of 1 year

    The investigators compared platelet values between group with low creatinine level and control group

  6. Number of patients who receive blood products transfusion

    Time frame: Through study completion, an average of 1 year

    The investigators compared number of patients who received blood products between group with low creatinine level and control group

  7. Number of patients discharged

    Time frame: Through study completion, an average of 1 year

    The investigators compared number of patients who were discharged from intensive care unit to the ward between group with low creatinine level and control group

Sponsors and collaborators

Lead sponsor

Osijek University Hospital

Other

Collaborators

  • Josip Juraj Strossmayer University of Osijek

Registry information

Official study title

A Correlation of Low Serum Creatinine Levels and Respiratory Function in the Mechanically Ventilated Patients in the Intensive Care Unit

Important dates

Study start
2015
Primary completion
2016
Study completion
2017
First posted
Apr 29, 2020
Registry last updated
Apr 29, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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