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NCT Number: NCT06871371

Low and Moderete Flow Anaesthesia on Haemodynamics

The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.

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Key information

Conditions

Hemodynamics Instability Arrhythmias Cardiac Arrhythmias, Cardiac Cardiovascular Diseases Cerebral Oxygenation Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

17 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Umraniye Education and research hospital

Istanbul, 34111, Turkey (Türkiye)

About this study

The study aims to compare the effects of low and normal flow sevoflurane anesthesia on the frontal QRS-T angle and cerebral oxygenation in laparoscopic cholecystectomy surgery. The primary objective was to evaluate the effects of low-flow anesthesia on hemodynamic stability and arrhythmia risk; the secondary objective was to compare the total sevoflurane consumption in both methods.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • being ASA1-2 status
  • between the ages of 18-70
  • who are planned for laparoscopic cholecystectomy

Exclusion criteria

  • Patients who refuse to give informed consent
  • Pregnant and breastfeeding patients
  • Morbidly obese patients (Body mass index over 40)
  • Patients with uncontrolled diabetes mellitus, with serious cardiovascular, pulmonary, renal, hepatic disease, obstructive sleep apnea, with electrolyte imbalance- Those with a history of alcohol or drug abuse, with perioperative hemodynamic instability
  • Patients using drugs known to prolong myocardial repolarization
  • inability to increase SPO2 above 95 despite necessary intervention

Treatment and study plan

Sevoflurane (Volatile Anesthetic)

Device

Both groups will be given sevoflurane and one group will be given low current anesthesia and the other group will be given medium flow anesthesia.

low- medium flow anesthetic machine

Device

The study aims to compare the effects of low and normal flow sevoflurane anesthesia on the frontal QRS-T angle and cerebral oxygenation in laparoscopic cholecystectomy surgery.

Primary outcomes

  1. the effects of low-flow anesthesia on hemodynamic stability

    Time frame: in 2 months

    The primary objective was to detect the adverse effects of low-flow anesthesia on hemodynamic stability and arrhythmia risk

Secondary outcomes

  1. the cerebral oxygenation

    Time frame: in 2 months

    The primary objective was to detect the adverse effects of low-flow anesthesia on cerebral oxygenation

Study contacts

Contact information is provided by the study sponsor or research team.

senay goksu, specialist doctor

CONTACT

[email protected]

+905337144852

Sponsors and collaborators

Lead sponsor

Umraniye Education and Research Hospital

Other Gov

Registry information

Official study title

The Comparison of the Effects of Low and Medium Flow Anesthesia on Haemodynamics, Arrhytmia Risk and Cerebral Oxygenation in Laparoscopic Cholecystomy Cases

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 11, 2025
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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