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NCT Number: NCT07287891

Lost in the Labyrinth: Predicting Central Neurological Causes of Vertigo Dizziness and Unsteadiness in the Emergency Department. A Multicentre Cross-sectional Observational Study

This study will assess the sensitivity and specificity of the bedside examination algorithm performed by ED physicians. Finally, it aims to identify predictors of a central cause of the symptoms. This will consequently reduce the rate of misdiagnosis as well as the costs and length of stay due to inappropriate neuroimaging.

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Key information

Conditions

ED With Vertigo Dizziness Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Unsteadiness

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

SC Pronto Soccorso e Medicina d'Urgenza, Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy

Location status: Recruiting

Location contact

Marco Bonzano, MD

CONTACT

[email protected]

+390380502039

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting at the ED with vertigo, dizziness or unsteadiness
  • >= 18 years of age
  • Patients able to give their consent

Exclusion criteria

  • Patients with dementia
  • Bedridden patients (for causes other than the current symptoms)
  • Patients with obvious neurological findings presenting with vertigo but with suspected stroke at triage

Treatment and study plan

Bedside examination of Vertigo

Diagnostic Test

ED visit comprehensive of bedside examination of vertigo performed by trained EP or emergency medicine residents

Primary outcomes

  1. The AUC of the bedside examination algorithm performed by ED physicians

    Time frame: up to 36 months

Secondary outcomes

  1. identification of predictors of true positive patients

    Time frame: up to 36 months

    Predictors of true positive patients can help to stratify patients with vertigo for the risk of stroke.

  2. evaluation of number of neuroimaging tests (TC and angio-TC) performed to patients with vertigo in the ED.tests performed

    Time frame: up to 36 months

    to study the use of ED resources for these patients in terms of number of neuroimaging tests performed.

Study contacts

Contact information is provided by the study sponsor or research team.

Marco Bonzano, MD

CONTACT

[email protected]

+390382502039

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Acronym: VERTIGO

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Dec 17, 2025
Registry last updated
Dec 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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