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NCT Number: NCT07477106

Longitudinal Prospective Study of Maternal and Child Nutrition in Arkansas

The investigators want to learn how women's diets may impact breastfeeding outcomes. This study will help the investigators learn more about how diet and social factors like food access may impact mothers' health, breastfeeding, and their baby's health. Participants will attend a visit before birth, then 11 visits as their baby grows up. All visits will be remote using RedCap, phone or video call, text messaging or any other communication modalities of preference to the participant. The investigators will ask for personal information about participants' family, home, and finances, health literacy, medical history, current medications, pregnancy complications, mental health (depression, quality of life), confidence in breastfeeding, eating habits, and plan to feed their baby. After childbirth, the investigators will ask about participants' delivery and child's health, and request access to their child's medical records. Across all visits, the investigators will ask participants to measure their weight, height, blood pressure, activity and sleep, and child's length; the investigators will also ask them to ship urine, stool, and breast milk samples. The investigators will obtain a 24-hour feeding log for the child, as well as a log of what the mother ate and drank over 24 hours.

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Arkansas Children's Research Institute

Little Rock, Arkansas, 72202, United States

Location contact

Aline Andres, PhD, RD, CLC

PRINCIPAL_INVESTIGATOR

Audrey Martinez, PhD, RD

CONTACT

[email protected]

5013642785

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 30 weeks pregnant
  • Ability to engage in study procedures throughout the first 12 months postpartum

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Maternal dietary intake

    Time frame: Third trimester of pregnancy and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 months postpartum

    24 hour dietary recall using ASA24

  2. Child dietary pattern

    Time frame: 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month of age

    24 hour recall using NDSR

  3. Breastfeeding outcomes

    Time frame: 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month postpartum

    Exclusivity, duration and mixed feeding

Secondary outcomes

  1. Maternal weight

    Time frame: Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18 and 24 month postpartum

    Smart scale

  2. Human milk composition

    Time frame: 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 month postpartum or as long as lactating

    macronutrients, micronutrients and non-nutritive components

  3. Blood pressure

    Time frame: Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 month postpartum

    Smart device, at home collection

  4. Physical activity

    Time frame: Third trimester and 0.5, 1, 2, 3, 4, 5, 6, 9, 12, 18, 24 months postpartum

    Accelerometry

Sponsors and collaborators

Lead sponsor

Arkansas Children's Hospital Research Institute

Other

Registry information

Official study title

Longitudinal Prospective Study of Maternal and Child Nutrition in Arkansas - The Thrive Study

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Mar 17, 2026
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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