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NCT Number: NCT04330599

Longitudinal Population-based Observational Study of COVID-19 in the UK Population

COVIDENCE UK is a population-based observational longitudinal study that has the following objectives:

1. To determine risk factors for incident COVID-19 and for adverse outcomes of COVID-19 in the UK population 2. To characterise the natural history of COVID-19 in the UK population 3. To evaluate the impact of COVID-19 on the physical and mental health of the UK population 4. To provide a resource from which to identify potential participants for future clinical trials, and to use data collected in COVIDENCE as comparison or control data for trial participants who have been randomised to receive one or more interventions.

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Key information

Conditions

COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Queen Mary University of London

London, County (optional), E1 2AB, United Kingdom

Location status: Recruiting

Location contact

Adrian R Martineau, MD PhD

CONTACT

[email protected]

02078822551

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • UK resident
  • Age ≥16 years

Exclusion criteria

none

Treatment and study plan

Primary outcomes

  1. Incidence of confirmed COVID-19

    Time frame: 5 years

Secondary outcomes

  1. Incidence of probable or suspected COVID-19

    Time frame: 5 years

  2. Incidence of COVID-19 requiring hospitalisation

    Time frame: 5 years

  3. Incidence of COVID-19 requiring ventilatory support

    Time frame: 5 years

  4. Incidence of fatal COVID-19

    Time frame: 5 years

  5. Symptom duration per COVID-19 episode

    Time frame: 5 years

  6. Symptom severity per COVID-19 episode

    Time frame: 5 years

  7. Incidence of seroconversion to SARS-CoV-2

    Time frame: 5 years

  8. Incidence of recurrent COVID-19

    Time frame: 5 years

  9. EQ-5D-3L health-related quality of life score

    Time frame: 5 years

  10. Health care costs associated with incident COVID-19

    Time frame: 5 years

  11. Impact of the COVID-19 pandemic and the societal response on participants' financial status

    Time frame: 5 years

  12. Incidence of COVID-19 on participant's physical health

    Time frame: 5 years

  13. Impact of COVID-19 on participants' mental health

    Time frame: 5 years

  14. Impact of COVID-19 on physical health of offspring born to participants during follow-up

    Time frame: 5 years

Study contacts

Contact information is provided by the study sponsor or research team.

Adrian Martineau, PhD

CONTACT

[email protected]

+442078822551

Hayley Holt, MSc

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Queen Mary University of London

Other

Collaborators

  • Barts & The London NHS Trust
  • King's College London
  • London School of Hygiene and Tropical Medicine
  • Queen's University, Belfast
  • Swansea University
  • University of Edinburgh

Registry information

Acronym: COVIDENCE UK

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Apr 1, 2020
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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