Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Completed

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Key information

Conditions

Overweight and Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
Nonobese (BMI ≥ 25 kg/m2)

Exclusion criteria

Current and/or past history of cardiovascular disease
Diabetes mellitus (fasting glucose levels ≥126 mg/dL)
Abnormal liver or renal function
Thyroid or pituitary disease
Pregnancy or lactation
Regular use of any medication

Treatment and study plan

rs662799 (APOA5 -1131T>C)

Genetic

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T>C polymorphism.

Primary outcomes

Brachial-ankle PWV (baPWV)

Time frame: at baseline

cm/s
Brachial-ankle PWV (baPWV)

Time frame: 3-year follow-up

cm/s

Secondary outcomes

Triglyceride

Time frame: at baseline

mg/dL
Triglyceride

Time frame: 3-year follow-up

mg/dL

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

Longitudinal Interaction Between APOA5 -1131T>C and Overweight

Important dates

Study start: 2008
Primary completion: 2013
Study completion: 2013
First posted: Dec 8, 2017
Registry last updated: Dec 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed