Longevity of Microwave Thermolysis and Botulinum Toxin A for Treatment of Axillary Hyperhidrosis

Inclusion criteria

• Subject has provided written informed consent
• Subject is 18 years of age or older
• A unilateral HDSS score of 3 or 4 for each axilla
• A gravimetric measurement of at least 50 mg/5 min for women and 100 mg/5 min for men in at least one axilla. The contralateral axilla should not be below 40 mg (women) and 80 mg (men).
• Women of childbearing potential must be confirmed not pregnant by a negative u-HCG prior to study treatment and must use a safe contraceptive method at baseline.

Exclusion criteria

• Subjects with generalized hyperhidrosis
• Medical condition or medications that may alter perspiration (e.g. metabolic, immunological or infectious diseases, antidepressants, opioids, adrenergic/cholinergic drugs)
• Daily use of systemic or topical antibiotics and/or steroids in axillae at the time of inclusion
• Topical treatments for axillary hyperhidrosis (anti-perspirants are allowed except for visit days)
• Abnormal skin (e.g. rash, infection, dermatitis) in the axilla at the time of inclusion
• Breast tissue in the axillae
• Treatment with Isotretinoin within the past 6 months
• Axillary laser or IPL treatment within the past 6 months
• Botulinum toxin-injections in the axillae within the past 12 months prior to baseline
• Known allergies to botulinum toxin, iodine, lidocaine or adrenaline
• Prior axillary surgery
• Limited motion in the shoulder joint or neurologic deficit in upper limb
• History of diseases resulting in muscle weakness (ALS, Lou Gehrig's), dysphagia (Myasthenia Gravis or Lambert Eaton Syndrome) or respiratory compromise
• Axillary lymph node enlargement or -removal or lymphedema in either upper limb
• History of hidradenitis suppurativa or history of reoccurring infections/abscesses
• History of breast cancer
• Electronic device implant
• If female; lactating, pregnant or planning on becoming pregnant during the study
• Non-eligibility at the discretion of the investigator (e.g. non-compliance, unavailability or other reasons the subject is not believed to be able to comply with the clinical trial protocol)