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Recruiting

NCT Number: NCT06374069

Longevity Families of the Netherlands

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.

The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Recruiting

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Key information

Conditions

Longevity Aging Extreme Longevity Familial Longevity

Age range

75 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Leiden University Medical Center

Leiden, South Holland, 2333ZA, Netherlands

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
  • Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Identifying the genetic variants of Familial Longevity

    Time frame: through study completion, an average of 2 years

    To identify gene variants associated with healthy aging and protection from (multi)morbidity

Secondary outcomes

  1. Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component

    Time frame: through study completion, an average of 2 years

    To study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component

Study contacts

Contact information is provided by the study sponsor or research team.

(Eline) P. Slagboom, Prof. dr.

CONTACT

[email protected]

+31(0)71 5269 730

Sponsors and collaborators

Lead sponsor

Leiden University Medical Center

Other

Collaborators

  • Jacobijn Gussekloo, Prof. dr.
  • Simon P. Mooijaart, Prof. dr.

Registry information

Acronym: LOF-NL

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Apr 18, 2024
Registry last updated
Apr 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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