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NCT Number: NCT07465692

Long-term Results of Rehabilitation of Patients With Myocardial Infarction After Coronary Artery Stenting. The Register.

Endovascular intervention is one of the most effective treatment for acute coronary syndrome. Therefore, studying the impact of various medical rehabilitation programs on the course of coronary heart disease, patient quality of life, restenosis, and prognosis is of scientific and practical interest. Medical rehabilitation is a crucial stage in patient care after myocardial revascularization. Regular moderate-intensity physical activity helps improve endothelial function and has anti-inflammatory and antithrombogenic effects. Improving a patient's prognosis after myocardial infarction depends on the duration and intensity of cardiac rehabilitation programs, as well as the patient's motivation. Therefore, this issue requires further study, particularly in patients who have undergone endovascular interventions on coronary arteries.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The study was an interventional (clinical) trial, randomized in parallel groups. A total of 1,046 patients were included.

A total of 1,046 patients of both sexes were randomized into two groups. Group 1 (control) patients received standard therapy required for patients undergoing coronary artery stenting during the acute phase of myocardial infarction. They continued their usual physical activity and attended a school for patients with myocardial infarction. Group 2 patients received standard therapy required for patients undergoing coronary artery stenting during the acute phase of myocardial infarction, attended a school for patients with myocardial infarction, and participated in a physical training program. The training program lasted over four months. Postoperatively, patients underwent blood tests, echocardiography, ECG, and bicycle ergometry. The next visit was performed after an average of eight years (with a maximum follow-up period of 11 years). Cardiovascular events were assessed at this stage. Patients who were unable to attend the clinic were interviewed by telephone.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute myocardial infarction, coronary artery stenting

Exclusion criteria

  • Age (younger 18 years, older 75 years)

Treatment and study plan

Physical training program

Other

Integrated Rehabilitation consisting of exercise training for at least 1.5 months

Primary outcomes

  1. Combined

    Time frame: 20 years

    Cardiovascular mortality, non-fatal acute myocardial infarction, non-fatal stroke, need for revascularization

Secondary outcomes

  1. All-cause mortality

    Time frame: 20 years

  2. Composite endpoint of major adverse cardiovascular events (MACE)

    Time frame: 20 years

    Composite endpoint of major adverse cardiovascular events (MACE), defined as the first occurrence of any of the following: recurrent myocardial infarction, ischemic or hemorrhagic stroke, repeat coronary revascularization (PCI or CABG), cardiovascular death.

  3. cardiovascular mortality

    Time frame: 20 years

  4. myocardial infarction

    Time frame: 20 years

  5. stroke

    Time frame: 20 years

  6. need for revascularization

    Time frame: 20 years

  7. hospitalization due to cardiovascular complications

    Time frame: 20 years

Sponsors and collaborators

Lead sponsor

National Medical Research Center for Therapy and Preventive Medicine

Other Gov

Registry information

Official study title

Long-term Results of Rehabilitation of Patients With Myocardial Infarction After Endovascular Intervention on Coronary Arteries at the Outpatient Stage. Register

Important dates

Study start
2013
Primary completion
2026
Study completion
2026
First posted
Mar 12, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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