NCT Number: NCT06290726
Long-term Outcomes of Living Donor Liver Transplantations With Anti-HBc (+) Grafts in Pediatric Patients
The goal of this observational study is to compare in anti-HBc (+) grafts/ anti-HBc (-) grafts. The main question it aims to answer is the long-term efficacy of active vaccination and graft/patient outcomes of anti-HBc (+) grafts have yet to be comprehensively investigated. Researchers will compare anti-HBc (+) grafts/ anti-HBc (-) to see if it would affect the long-term survival.
Looking for future studies?
Notify MeKey information
Age range
4 month–18 year
Sex eligibility
All sexes
Study type
Observational
About this study
A particular strength of the present study is in the inclusion of a consecutive cohort of pediatric LDLT recipients with long-term details of follow-up, although there are several limitations. First, this was a retrospective study conducted at a single medical center. Second, the HBV prophylaxis changed from lamivudine to entecavir in 2008, therefore investigators were unable to evaluate the risk of developing lamivudine resistance. In addition, the DNA level data for the donor and graft tissues were lacking. Lastly, this study was conducted in an area with a high prevalence of anti-HBc positivity.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- consecutive pediatric LDLT recipients.
Exclusion criteria
- Adult LDLT recipients
Treatment and study plan
Primary outcomes
-
Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts
Time frame: Feb. 2002-Feb.2016
Investigation of the Long-term survival in pediatric recipients of living donor liver transplantations with anti-HBc (+) grafts
Sponsors and collaborators
Lead sponsor
Chang Gung Memorial Hospital
Other
Registry information
Official study title
Long-term Outcomes of Active Vaccination Against de Novo Hepatitis B Among Pediatric Recipients of Living Donor Liver Transplantations With Anti-HBc (+) Grafts
Important dates
- Study start
- 2002
- Primary completion
- 2016
- Study completion
- 2024
- First posted
- Mar 4, 2024
- Registry last updated
- Mar 5, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.