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NCT Number: NCT07312058

Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology

Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity.

Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.

However, few studies have analyzed the long-term reproductive outcomes of these interventions, nor how patients ultimately use or do not use the FP options once in remission.

This project aims to better understand the effectiveness, utilization, and psychological impacts of these strategies.

This work is part of an effort to understand and evaluate fertility preservation practices implemented for women of reproductive age undergoing cancer treatment at the Amiens-Picardie University Hospital (CHU).

Its objective is to document patient pathways, clinical decisions, techniques employed, and reproductive outcomes observed after remission, in order to identify potential areas for improvement in the support and follow-up of these patients, thereby enhancing the overall quality and coordination of care.

This work is conducted alongside the development of a fertility observatory at the Department of Medicine and Reproductive Biology, CHU Amiens-Picardie.

Recruiting

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Key information

Age range

18 year–47 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens Picardie

Amiens, France

Location status: Recruiting

Location contact

Rosalie Cabry, Pr

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women
  • Aged between 18 and 47 years
  • Diagnosed with cancer or hematological disorders requiring potentially gonadotoxic treatment
  • Having undergone a medical fertility preservation consultation
  • Followed at Amiens Picardie University Hospital (CHU Amiens Picardie) in the department of Reproductive Medicine
  • Currently in remission
  • Having expressed non-opposition to participation in the study

Exclusion criteria

  • Absence of remission
  • Patients deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curators)
  • Decline to participate in the study

Treatment and study plan

Primary outcomes

  1. Occurrence of an identifiable reproductive outcome

    Time frame: 1 year

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

Secondary outcomes

  1. Type of fertility preservation method performed

    Time frame: 1 year

  2. Time interval (in months) between diagnosis and fertility preservation

    Time frame: 1 year

  3. Correlation between Age and occurance of an identifiable reproductive outcome

    Time frame: 1 year

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

  4. Time interval (in months) between fertility preservation and initiation of potentially gonadotoxic treatment

    Time frame: 1 year

  5. Number of type of cancer associated with identifiable reproductive outcome

    Time frame: 1 year

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

  6. Correlation between type of treatment and occurence of an identifiable reproductive outcome

    Time frame: 1 year

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

  7. Correlation between family status and occurence of an identifiable reproductive outcome

    Time frame: 1 year

    Identifiable reproductive outcome are Spontaneous pregnancy, Use of preserved gametes or ovarian tissue (whether or not resulting in pregnancy), Use of donor oocytes, Discontinuation of the parenthood project

  8. Time interval (in months) between completion of treatment and pregnancy attempt (spontaneous or medically assisted)

    Time frame: 1 year

  9. Actual utilization rate of preserved material

    Time frame: 1 year

  10. Success rate of reuse attempts

    Time frame: 1 year

  11. Proportion of patients who ultimately did not pursue parenthood

    Time frame: 1 year

Study contacts

Contact information is provided by the study sponsor or research team.

CABRY-GOUBET Rosalie, Pr

CONTACT

[email protected]

33+3 22 08 80 00

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: FERT-ISSUES

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Dec 31, 2025
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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