Long-Term Effects of Treatment in Patients Previously Treated for Childhood Hodgkin's Lymphoma

OBJECTIVES:

• Determine the cumulative incidence and characterize the spectrum of selected adverse physiologic and psychosocial outcomes, using self-report and clinical evaluation, in patients previously treated for childhood Hodgkin's lymphoma.
• Compare the cumulative incidence and spectrum of self-reported adverse outcomes of these patients, using data collected at a comparable time period after diagnosis, with Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).
• Compare self-reported health-related outcomes with outcomes detected by clinical evaluation and medical record review of each group of patients.

OUTLINE: This is a cohort, cross-sectional, multicenter study.

• Contemporary group: Patients complete a self-report of long-term outcomes questionnaire and a comprehensive psychosocial questionnaire. A medical record review is then performed. Patients then undergo a comprehensive risk-based clinical evaluation with specific examinations and studies based upon the Children's Oncology Group Late Effects Screening Guidelines and the patients' specific therapeutic exposures.
• Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview and have medical records reviewed to validate select self-reported long-term outcomes. Patient replies from the baseline CCSS questionnaire (which was completed at certain timepoints after diagnosis) are reviewed for targeted long-term outcomes.

PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

• Contemporary cohort

• At least 5 years since diagnosis of Hodgkin's lymphoma

• Diagnosed between the years 1987-2001
• 21 and under at diagnosis
• No evidence of disease
• Prior treatment on 1 of the following protocols during the years 1987-2001:

• Children's Cancer Group (CCG) CCG-5942, CCG-59704
• Pediatric Oncology Group (POG) POG-8625, POG-8725, POG-9425, POG-9426
• Pediatric Hodgkin's Consortium: VAMP, VEPA, VAMP/COP
• Institutional protocols COPP/ABV, MOPP/ABVD, ABVD
• Childhood Cancer Survivor Study (CCSS) Hodgkin's lymphoma cohort

• Current enrollment in the CCSS
• Diagnosed between the years 1976-1986
• Completed baseline questionnaire at comparable timepoints (as the contemporary cohort) after diagnosis

PATIENT CHARACTERISTICS:

Age

• Any age

Performance status

• Not specified

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Not specified

Renal

• Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Not specified

Chemotherapy

• Not specified

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified