Long Term Effect of Splenectomy on Metabolism

Metabolic status of patients who had gone through trauma splenectomy between July 2008 and July 2013 were compared to patients who had gone through bowel resection due to obstruction in the same period of time. all patients were followed up for 5-10 years.

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Key information

Conditions

Trauma Splenic Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

A list was made of patients who had gone through trauma splenectomy or bowel resection due to bowel obstruction in our center between July 2008 and July 2013. Patients were divided into two groups: trauma splenectomy (exposed group) and bowel resection (unexposed group).

All patients were followed up for 5-10 years. Of the 243 splenectomized patients, 90 patients who met our study criteria were willing to participate. Of 152 patients with bowel resection, 64 were willing to participate. Records of patients at the time of surgery were retrieved from hospital archive of patients' records. Patients were invited to an office meeting for assessment of blood pressure, BMI and a general physical examination and history taking. An appointment was made for drawing blood samples for measurement of lipid profile, Hb A1C and fasting blood sugar.

Exclusion criteria

Disturbed lipid profile at the time of surgery, 2. Disturbed blood glucose levels at the time of surgery, 3. History of high blood pressure prior to surgery, 4. Use of any hyperglycemogenic agent during the follow up period, 5. BMI>= 25 at the time of surgery, 6. History of diseases potentially affecting blood glucose, e.g. hyperthyroidism, Cushing syndrome, 7. Accidental pancreatic damage during surgery, 8. Resection of >10 cm of small bowel and 9. History of malignancy or radiotherapy (criteria 8 and 9 were specific to unexposed group).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

trauma splenectomy or bowel resection due to obstruction between July 2008 and July 2013

Exclusion criteria

disturbed lipid profile at the time of surgery
disturbed blood glucose at the time of surgery
history of high blood pressure at the time of surgery
use of any hyperglcemogenic agent during the follow up
BMI>= 25 at the time of surgery
history of diseases that can affect blood glucose levels
accidental pancreatic damage during surgery
resection of > 10 cm of small bowel (for bowel resection group)
history of malignancy or radiotherapy (for bowel resection group)

Treatment and study plan

Blood sample

Diagnostic Test

Blood sample for Hb A1C and lipid profile, blood pressure and BMI

Other names: BMI and blood pressure measurement

Primary outcomes

Glucose tolerance

Time frame: July 2008- July 2013

Glucose tolerance was assessed by measuring the Hb A1C of the patients in both groups.

Sponsors and collaborators

Lead sponsor

Imam Hossein General Hospital

Other

Registry information

Official study title

Long-term Effect of Splenectomy on Metabolism, a Retrospective Cohort Study

Important dates

Study start: 2008
Primary completion: 2018
Study completion: 2018
First posted: Aug 27, 2018
Registry last updated: Aug 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed