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Completed

NCT Number: NCT01453699

Long-term Consequences of Bereavement in Children, Adolescents and Young Adults

The purpose of this study is to examine how the death of a parent as a child, adolescent or young adult affects health and psychosocial wellbeing in adult life and to evaluate the impact in adult life of counseling to children, adolescents and young adults who lost a parent.

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Key information

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Psychosocial Cancer Research, Institute of Cancer Epidemiology, Danish Cancer Society

Copenhagen, 2100, Denmark

About this study

Early parental death experienced by 4% of the children in Western countries, is considered to be the most stressful and potentially harmful childhood life event and the health consequences may depend on the nature of the bereavement (e.g. relationship with bereaved), as well as by interpersonal (e.g. social support), intrapersonal (e.g. age and genetics), appraisal and coping factors. Studies have shown that children and adolescents have a greater risk of getting a psychiatric diagnose as well as psychological and social problems. Despite of the obvious consequences of losing a parent, there is a lack of systematic studies on the consequences later in life as well as studies that evaluate the counseling possibilities the children and adolescents are offered.

The study will investigate:

  • Long-term health effects of experiencing parental death as a child adolescent or young adult. Focus will be on psychiatric outcomes including depression, severe cardiovascular disease, suicide, suicide attempts, psychological well-being and health related behavior.
  • Long term effects of experiencing parental death as a child, adolescent or young adult on socioeconomic outcomes as education, employment, marital status/ cohabitation status and number of children/age when having children.
  • The long-term psychosocial and behavioral impact of psychological intervention programmes to children, adolescents and young adults who have experienced the death of a parent. Focus will be on: Depressive symptoms, quality of life, posttraumatic stress disorder, life style, relationship functioning, grief and spirituality.

A nationwide register based cohort of people born in Denmark will be established. Long-term health effects and socioeconomic outcomes of experiencing parental death will be based on nationwide clinical and administrative registries. Exposure is defined as experiencing the death of a parent before age 30. The long-term psychosocial and behavioral impact of psychological intervention programmes will be based on a combination of questionnaire data and data from registries.

The part of the study using data from registries will be based on the nationwide cohort. The questionnaire based part of the study will include 3 groups selected from the nationwide cohort:

  • Persons who have lost a parent and participated in intervention programmes (identified through counseling centers),
  • Persons who have lost a parent, and not participated in intervention programmes (randomly selected matched on age and gender) and
  • Persons who have not lost a parent (randomly selected matched on age and gender).

An invitation letter will be send to the 3 groups (5500 persons) by mail, and they will be asked to complete one questionnaire online.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • persons born in Denmark

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Hospitalization for affective disorder

    Time frame: Paticipants will be followed from age 15 until date of first hospitalization for an affective disorder, death, first emigration or end of follow up, an expected average of 12 years

    Danish Psychiatric Central Register

  2. Use of antidepressive medication

    Time frame: Paticipants will be followed from age 20 until date of second independantly prescription of antidepressive medication, death, first emigration or end of follow up, an expected average of 9 years

    The Danish National Prescription Registry

  3. Suicide

    Time frame: Paticipants will be followed from age 18 until date of suicide, other causes of death, first emigration or end of follow up, an expected average of 15 years

    Danish Register of Causes of Death

  4. Severe cardiovascular disease

    Time frame: Paticipants will be followed from age 18 until date of first hospitalization for severe cardiovascular disease, death, first emigration or end of follow up, an expected average of 15 years

    The Danish National Patient Register

  5. Education level

    Time frame: Participants will be followed from age 18 until highest attained educational level, death, first emigration or end of follow up, an average of 20 years

    The Register-based System of Demographics and Social Statistics in Denmark

  6. Employment

    Time frame: Employment status at age 30, death, first emigration or end of follow-up, an expected average of 8 years.

    The Register-based System of Demographics and Social Statistics in Denmark

  7. Quality of life

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    SF-36, Self-reported questionnaire

  8. Complicated grief

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Inventory of Complicated Grief/ Prolonged Grief Disorder (PG-13) and Centrality of Event Scale, Self-reported questionnaire

  9. PTSD

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Harvard Trauma Questionnaire (HTQ), Self-reported questionnaire

  10. Existentiality

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Posttraumatic Growth Inventory (PTGI, Self-reported questionnaire

  11. Depressive symptoms

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    The Center for Epidemiological Studies Depression Scale (CES-C)

Secondary outcomes

  1. Relationship functioning

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Quality of relationship and intimacy, Self-reported questionnaire

  2. Support when losing a parent

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Self-report items

  3. Lifestyle (smoking, alcohol, exercise)

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Self-reported questionnaire

  4. Coping

    Time frame: Participants will be answering the questionnaire once (not at a specifik age but between 18-40 years)

    Brief cope, Self-reported questionnaire

Sponsors and collaborators

Lead sponsor

Danish Cancer Society

Other

Collaborators

  • Center for Crisis Psychology
  • Children´s Welfare
  • Counselling and Research Center for Grieving Children, Teens and Young Adults
  • Statens Serum Institut

Registry information

Official study title

Bereavement in Children, Adolescents and Young Adults. - A Study of Health and Psychosocial Well-being in Adults Who Have Experienced Early Parental Death

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Oct 18, 2011
Registry last updated
Aug 12, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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