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NCT Number: NCT07482228

Long-term Clinical Outcomes After Retinal Artery Occlusion

Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries. Patients with RAO are known to have an increased risk of subsequent cardiovascular and cerebrovascular events, including ischemic stroke and myocardial infarction. However, long-term outcomes and optimal medical treatment strategies for these patients remain insufficiently characterized.

The purpose of this nationwide population-based study is to investigate the incidence of long-term cardiovascular and cerebrovascular outcomes in patients diagnosed with retinal artery occlusion using the Korean National Health Insurance Service (NHIS) database. In addition, the study aims to evaluate the impact of various medical therapies, including antiplatelet agents, anticoagulants, and statins, on long-term clinical outcomes.

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Key information

Conditions

Retinal Artery Occlusion Arterial Occlusive Diseases Cardiovascular Diseases Eye Diseases Retinal Diseases Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Chonnam National University Hospital

Gwangju, 61469, South Korea

Location status: Recruiting

Location contact

Seung Hun Lee, MD, PhD

CONTACT

[email protected]

82-62-220-6246

Seung Hun Lee, MD, PhD

PRINCIPAL_INVESTIGATOR

About this study

Retinal artery occlusion (RAO) is an acute retinal vascular disease that results in sudden and severe vision loss. RAO is typically classified into central retinal artery occlusion (CRAO) and branch retinal artery occlusion (BRAO), depending on the site of arterial obstruction. CRAO generally has a worse clinical prognosis compared with BRAO.

Previous studies have demonstrated that RAO is associated with systemic vascular diseases and an increased risk of ischemic stroke and other cardiovascular events. Despite its clinical significance, effective evidence-based treatment strategies for RAO remain unclear.

This study aims to evaluate the epidemiology and long-term cardiovascular outcomes of patients with RAO in Korea using the National Health Insurance Service (NHIS) database, which covers nearly the entire Korean population. Patients newly diagnosed with RAO between January 2010 and December 2024 will be identified.

This nationwide population-based study may help clarify the long-term prognosis of RAO and identify optimal medical treatment strategies for improving clinical outcomes in these patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients newly diagnosed with retinal artery occlusion

Exclusion criteria

  • Patients with a prior diagnosis of retinal artery occlusion before the study period.
  • Patients diagnosed with giant cell arteritis.

Treatment and study plan

retinal artery occlusion

Other

treatment for retinal artery occlusion

Primary outcomes

  1. Occurrence of MACCE

    Time frame: up to 5 years

    major adverse cardiovascular and cerebrovascular event

Secondary outcomes

  1. Occurrence of all-cause death

    Time frame: up to 5 years

    Death from any causes

  2. Occurrence of cardiac death

    Time frame: up to 5 years

    Death from cardiac causes

  3. Occurrence of myocardial infarction

    Time frame: up to 5 years

    Myocarrdial infarction

  4. Occurrence of revascularization

    Time frame: up to 5 years

    Percutaneous coronary intervention or coronary artery bypass grafting

  5. Occurrence of stroke

    Time frame: up to 5 years

    Ischemic or hemorrhagic stroke

  6. Occurrence of admission due to heart failure

    Time frame: up to 5 years

    Hospital admission due to heart failure

  7. Occurrence of atrial fibrillation

    Time frame: up to 5 years

    Newly developed atrial fibrillation

  8. Occurrence of major and clinically relevant non-major bleeding

    Time frame: up to 5 years

    Major and clinically relevant non-major bleeding

Study contacts

Contact information is provided by the study sponsor or research team.

Seung Hun Lee, MD, PhD

CONTACT

[email protected]

82-62-220-6246

Sponsors and collaborators

Lead sponsor

Chonnam National University Hospital

Other

Registry information

Official study title

Long-Term Cardiovascular and Cerebrovascular Outcomes After Retinal Artery Occlusion: A Nationwide Study

Acronym: CVO-RAO

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Mar 19, 2026
Registry last updated
Mar 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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