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OpenTrials
Completed

NCT Number: NCT01728012

Long-term Cardiovascular Risk Following Successful Renal Transplantation

Mineral metabolism disturbances occur early during the course of chronic kidney disease and eventually affect most patients. For how long such disturbances persist after a successful renal transplantation is mainly unknown. This study will investigate the prevalence of such disturbances in patients more than 10 years following a successful renal transplantation. The patients will be recruited from an existing registry in Norway.

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Key information

Conditions

Renal Transplant

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stavanger University Hospital

Stavanger, NO-4011, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Registered in the Norwegian Renal Registry
  • Documented elevated iPTH at Tx and 10 weeks post-tx
  • Well functioning transplant 10 years following tx
  • Signed informed consent

Exclusion criteria

  • Lack of ability to comply with the protocol
  • Refused written informed consent

Treatment and study plan

Primary outcomes

  1. Fibroblast growth factor 23 (FGF23)

    Time frame: More than 10 years after successful renal transplantation

    To evaluate the long-term effect of a successful renal transplant on this biomarker.

Secondary outcomes

  1. Intact parathyroid hormone (iPTH)

    Time frame: More than 10 years after successful renal transplantation

    To evaluate the long-term effect of a successful renal transplant on this biomarker.

  2. Klotho

    Time frame: More than 10 years after successful renal transplantation

    To evaluate the long-term effect of a successful renal transplant on this biomarker.

  3. Neutrophil gelatinase-associated lipocalin (NGAL)

    Time frame: More than 10 years after successful renal transplantation

    To evaluate the long-term effect of a successful renal transplant on this biomarker.

Sponsors and collaborators

Lead sponsor

Helse Stavanger HF

Other Gov

Registry information

Official study title

The Prevalence of Cardiovascular Risk Factors in Patients More Than 10 Years Following Successful Renal Transplant.

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Nov 16, 2012
Registry last updated
Aug 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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