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Completed

NCT Number: NCT02554864

Location of Injection of Local Anesthetics in the Adductor Canal Block

The adductor canal block (ACB) is the standard of care for analgesia after Anterior Cruciate Ligament (ACL) repair. ACB is performed by injecting local anesthetic (freezing) in the subsartorial canal in the thigh which is about 7-10cm long. Preliminary evidence suggests that different injection sites within the canal may produce different degrees of analgesia and quadriceps motor block. This trial seeks to determine the effects of various ACB injection sites on postoperative analgesia and motor power following ACL repair.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Women's College Hospital

Toronto, Ontario, M5S 1B2, Canada

About this study

Adductor canal block (ACB) is replacing femoral nerve block (FNB) as the peripheral nerve block of choice for knee surgery. The ACB aims to inject local anesthetics (LA) within the neurovascular sheath in the subsartorial adductor canal around the femoral nerve. The point where the sartorius muscle crosses over the femoral artery is generally the accepted site for performing ACB. Clinically, injecting LA in the adductor canal blocks the sensory innervation of the knee and thus offers pain relief that is similar to FNB while conserving motor power around the knee. While these benefits are desirable, the exact location for performing ACB that ensures these benefits, remains debatable. The subsartorial adductor canal itself is 7-10cm long and the anatomical location of the sensory and motor nerves that innervate the knee and its surrounding muscles in this canal may vary. This randomized controlled trial is designed to identify and refine the ACB technique by clinically determining the effects of various ACB injection locations on postoperative analgesia and quadriceps motor power following ACL repair.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients booked for anterior cruciate ligament surgery under general anesthesia
  • English speaking
  • BMI <38 kg/m2

Exclusion criteria

  • Refusal or inability to provide informed consent
  • Allergy to local anesthetics
  • Contraindication to regional anesthesia including coagulopathy or bleeding - diathesis
  • Infection
  • Nerve Injury at the site of the nerve block
  • Malignancy at the site of the nerve block
  • History of drug and/or alcohol dependence
  • History of long term opioid intake or chronic pain disorder
  • History of pre-existing neuropathy in the operative leg
  • History of significant psychiatric conditions that may affect patient assessment
  • Inability to understand the informed consent and demands of the study
  • Allergy to any of the components of multi-modal analgesic regimen
  • Revision ACL repair

Treatment and study plan

Lidocaine

Drug

Local anesthetic

Other names: Xylocaine

Ropivacaine

Drug

Local anesthetic

Other names: Naropin

Primary outcomes

  1. Cumulative 24 Hour Oral Morphine Equivalent Consumption

    Time frame: 24 hours

    Post-Operative Analgesia

  2. Motor Power - Peak Force as measured by a dynamometer

    Time frame: 30 Minutes post Block

    Percentage decrease in quadriceps motor strength at 30 minutes following adductor canal block compare to baseline

Secondary outcomes

  1. Opioid Consumption

    Time frame: During surgical procedure

    Intra-operative opioid consumption

  2. Total opioids in Post Anesthetics (PAC)

    Time frame: Total length of time in PACU (total time in minutes from arrival in PACU to discharge to the Surgical Day Care is between 60-180 minutes

    Cumulative oral morphine equivalent consumption in PACU

  3. Pain Scores - Questionnaire

    Time frame: 24 hours post block

    Area under the curve for rest pain scores plotted against time during the first 24 hours

  4. Quality of Recovery (QoR-15)

    Time frame: 24 hours postoperatively

    Quality of recovery measured using the QoR-15 at 24 hours postoperatively

  5. Patient Satisfaction - Questionnaire

    Time frame: 24 hours postoperatively

    Patient satisfaction with analgesia - NRS Pain Scale 0(no pain to 10(worst pain)

  6. Hospital Discharge (Time to hospital discharge)

    Time frame: Same day as surgical procedure

    Time to hospital discharge

  7. Nerve Block Complications

    Time frame: 24 hours postoperatively and 2 weeks postoperatively

    Presence/absence of nerve block complications during the first 24 hours postoperatively and 2 weeks after surgery

Sponsors and collaborators

Lead sponsor

Women's College Hospital

Other

Registry information

Official study title

Location of Injection of Local Anesthetics in the Adductor Canal Block: A Randomized Controlled Trial of the Effect on Postoperative Analgesia and Motor Power

Acronym: LILAC

Important dates

Study start
2016
Primary completion
2017
Study completion
2018
First posted
Sep 18, 2015
Registry last updated
Feb 27, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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