Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

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Key information

Conditions

Aging Alzheimer Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Dementia Alzheimers Dementia Frontotemporal Depression in Old Age Frontotemporal Dementia Frontotemporal Lobar Degeneration Mental Disorders Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Pick Disease of the Brain Synucleinopathies Tauopathies

Age range

60 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tai Po Hospital

Hong Kong

About this study

Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Right-handed as assessed by the Edinburgh Inventory
Able to attend TMS interventions
Consent
Independent in daily life activities

Exclusion criteria

Uncorrected visual or auditive deficits not allowing the realization of the test
Evolutive disease (such as cancer)
Neurological or psychiatric antecedent
Counter-indication to MRI

Treatment and study plan

Transcranial Magnetic Stimulation

Device

One time for each day, lasting for three weeks.

Primary outcomes

Scalp-to-cortex distance will be measured using geometric brain model

Time frame: Baseline

Scalp-to-cortex distance (SCD), as a geometric feature, will measured in the Brainsight TMS neuronavigation system.

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Official study title

Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE): A Project of MRI-informed Computational Head Model

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2025
First posted: Aug 1, 2023
Registry last updated: Jan 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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