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NCT Number: NCT04760301

Local Tranexamic Acid During Vaginal Hysteractomy to Reduce Blood Loss

Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation

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Key information

Conditions

Blood Loss Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year–90 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Meir Medical Center, Kfar Saba, Israel

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About this study

This randomized control trial will investigate whether local tranexamic acid is efficient for decreasing bleeding during vaginal hysterectomy.

The investigators will randomize local placebo (saline) vs. local 1 gr tranexamic acid; local 1gr tranexamic acid diluted in 10 ml saline and local 10 ml saline at the beginning of surgery.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20-90 years old female patients going through vaginal hysterctomy

Exclusion criteria

  • massive bleeding during operation due to major vessles injury
  • known coagulopathies
  • sensitivity to tranexamic acid
  • medical need in tranexamic acid administration during operation due to bleeding

Treatment and study plan

local tranexamic acid injection

Drug

local tranexamic acid injection to cervix- 1 g tranexamic acid diluted in 10 ml saline

Other names: Hexakapron

local normal saline injection to cervix

Other

local normal saline injection to the cervix- 20 ml saline

Primary outcomes

  1. Blood loss during operation - measure in ml

    Time frame: End of surgery

    At the end of the surgery, surgeon will measure the blood in the suction can

Study contacts

Contact information is provided by the study sponsor or research team.

Gal Cohen, M.D

CONTACT

[email protected]

0545915788

Yair Daykan, M.D

CONTACT

[email protected]

0542198231

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Official study title

Local Tranexamic Acid During Vaginal Hysterectomy to Reduce Blood Loss

Important dates

Study start
2021
Primary completion
2025
Study completion
2026
First posted
Feb 18, 2021
Registry last updated
May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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