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NCT Number: NCT07588295

Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease

Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.

This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.

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Key information

Conditions

Stable Coronary Artery Disease Acute Coronary Syndrome Acute Coronary Syndromes Arterial Occlusive Diseases Arteriosclerosis Atherosclerosis Cardiovascular Diseases Chronic Disease Chronic Limb-Threatening Ischemia Critical Limb Ischemia Disease Attributes Heart Diseases Intermittent Claudication Ischemia Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Peripheral Arterial Disease Peripheral Vascular Diseases Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maria Cecilia Hospital

Cotignola, Ravenna, 48033, Italy

Location status: Recruiting

Location contact

Roberto Nerla, MD, PhD

CONTACT

[email protected]

+390545217032

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with chronic coronary artery disease;
  • Patients with no-ST elevation acute coronary syndrome;
  • Patients with chronic claudication (Rutherford II-III)
  • Patients with critical limb ischemia (Rutherford IV-V).

Exclusion criteria

  • Severe renal dysfunction
  • Severe valve disease
  • Advanced heart failure
  • Advanced liver disease
  • Chronic inflammatory or autoimmune disease
  • Use of antinflammatory drugs
  • Acute infection
  • Recent surgical procedures

Treatment and study plan

Optical Coherence Tomography assessment

Diagnostic Test

assessment of the number of infiltrating macrophages

Primary outcomes

  1. presence of macrophages and their activation within coronary and peripheral atherosclerotic lesions

    Time frame: From enrollment to hospital discharge following peripheral angiography/coronary angiography

    To evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions (using OCT imaging), and to correlate these findings with the distribution of circulating monocyte subpopulations.

Study contacts

Contact information is provided by the study sponsor or research team.

Roberto Nerla, MD, PhD

CONTACT

[email protected]

+390545217032

Sponsors and collaborators

Lead sponsor

Maria Cecilia Hospital

Other

Registry information

Official study title

Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
May 14, 2026
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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