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Enrolling by Invitation

NCT Number: NCT05329558

Local and Systemic Changes in Osteonecrosis of the Jawbone

Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.

Enrolling by Invitation

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Key information

Conditions

Osteonecrosis of the Jaw

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University of Graz

Graz, 8036, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • with/without ART
  • with/without MRONJ

Exclusion criteria

  • smoker (>10 cigarettes/day)
  • pregnancy

Treatment and study plan

Primary outcomes

  1. target gene expression

    Time frame: through study completion, an average of 1 year

    differences in gene expression recorded by qPCR will be assessed

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Pilot Study: Local and Systemic Changes in Osteonecrosis of the Jawbone

Acronym: SULVO

Important dates

Study start
2018
Primary completion
2026
Study completion
2026
First posted
Apr 15, 2022
Registry last updated
Apr 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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