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NCT Number: NCT02025023

Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study

Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.

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Key information

Conditions

Chalazion Cysts Eye Diseases Eyelid Diseases Neoplasms Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

University of Washington Eye Institute at Harborview

Seattle, Washington, 98104, United States

Location status: Recruiting

Location contact

Simona Vuletic

CONTACT

[email protected]

206-520-9728

About this study

This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Single or multiple chalazia in a single eyelid

Exclusion criteria

  • Chalazia present for less than one month and no previous injection or incision and curettage

Treatment and study plan

5-Fluorouracil injection

Drug

If the chalazion is present at follow-up visit, another injection of 5-FU will be given.

Other names: 5-FU

Triamcinolone Acetonide

Drug

If chalazion present at follow-up, another Triamcinolone injection will be done.

Other names: triamcinolone

Incision and Curettage

Procedure

If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.

Triamcinolone Acetonide/5-fluorouracil mixture

Drug

If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.

Primary outcomes

  1. Size of chalazion

    Time frame: 4 weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Ian Luttrell

CONTACT

[email protected]

206-520-8305

Simona Vuletic

CONTACT

[email protected]

206-520-9728

Sponsors and collaborators

Lead sponsor

University of Washington

Other

Registry information

Acronym: CTS

Important dates

Study start
2013
Primary completion
2025
Study completion
2026
First posted
Dec 31, 2013
Registry last updated
Feb 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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