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Completed

NCT Number: NCT01108250

LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.

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Key information

Conditions

Age-Related Macular Degeneration Eye Diseases Macular Degeneration Retinal Degeneration Retinal Diseases

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

In Taek Kim

Daegu, Kyungsangpookdo, 700-721, South Korea

About this study

This is a cross-sectional case-control study. One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Polypoidal choroidal vasculopathy group

Inclusion criteria

  • patients older than 60 years of age at onset
  • polyp-like terminal aneurysmal dilations with or without branching vascular networks in indocyanine green angiography and subretinal reddish-orange protrusions corresponding to polyp-like lesions

Exclusion criteria

  • eyes with pathologic myopia, angioid streaks, central serous chorioretinopathy, and other retinal or choroidal diseases

Control group

Inclusion criteria

  • individuals without retinal diseases and without any signs of polypoidal choroidal vasculopathy or age-related macular degeneration on the bases of comprehensive ophthalmic examination results

Treatment and study plan

LOC387715/HTRA1 genotyping

Genetic

Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.

Other names: genotyping

Primary outcomes

  1. Genotyping of LOC387715/HTRA1 of PCV and control groups

    Time frame: 4weeks

    to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV)

Secondary outcomes

  1. Indocyanine angiographic findings of polypoidal choroidal vasculopathy

    Time frame: 20 minutes

    The association of the risk allele of the LOC387715/HTRA1 and indocyanine angiographic characteristics of polypoidal choroidal vasculopathy including subretinal hemorrhage, pigment epithelial detachment, and serous retinal detachment.

  2. Visual acuity using Snellen chart

    Time frame: 2 x 5 minutes

    To evaluate the association between visual acuity and genotype of polypoidal choroidal vasculopathy

Sponsors and collaborators

Lead sponsor

Kyungpook National University Hospital

Other

Registry information

Acronym: PCV

Important dates

Study start
2010
Primary completion
2010
Study completion
2011
First posted
Apr 21, 2010
Registry last updated
Aug 30, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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