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NCT Number: NCT07125378

Living Independence Through Functional Training

The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.

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Key information

Conditions

Mobility Limitation Behavior Cognition Disorders Cognitive Dysfunction Cognitive Impairment Mental Disorders Motor Activity Neurocognitive Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • between the ages of 65 and 90 years
  • community-dwelling
  • live within a 50-mile radius of the study site with wireless connectivity in the area
  • mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before
  • cognitive decline as indicated by a score < 12 on Mini MoCA Version 2.1
  • a care partner or adult family member living in the home or nearby
  • willing to wear an activity tracker during the study period

Exclusion criteria

  • plan to receive skilled rehabilitation services
  • plan to move away outside the study area in two months
  • reside in an assisted living or long-term care facility or plan to relocate to such a facility in the next three months
  • severe vision or hearing loss that impedes activity performance or communication
  • unable to stand or walk even with a mobility aid
  • unable to follow a one-step command or carry on a conversation over the phone
  • unable to commit to the six-week exercise program
  • contradictions to resistance exercise, such as the end-stage heart failure
  • a terminal disease or on hospice care
  • a neurological condition affecting motor skills
  • not able to provide consent.

Treatment and study plan

Task-oriented resistance exercise

Behavioral

The intervention program includes progressive resistance exercise and daily activity exercise, delivered over a six-week period with an ideal frequency of three sessions per week. Progressive resistance exercise will be provided through a combination of in-person and online sessions, while daily activity exercise will be delivered exclusively in person.

Primary outcomes

  1. Short Physical Performance Battery

    Time frame: Baseline, 8 weeks, and 12 weeks.

    The score ranges from 0 to 12, with a score of 12 indicating the best physical functioning of the lower extremity.

  2. Montreal Cognitive Assessment

    Time frame: Baseline, 8 weeks, and 12 weeks.

    The score ranges from 0 to 30, with a score of 30 indicating the best global cognitive function.

Secondary outcomes

  1. Timed Up and Go Test-Single Task.

    Time frame: Baseline, 8 weeks, and 12 weeks.

    Time in seconds to complete the test, with a longer time indicating poor functional mobility.

  2. Timed Up and Go-Dual Task

    Time frame: Baseline, 8 weeks, and 12 weeks.

    Time in seconds to complete the task, a longer time indicating the interference of the dual task effect on mobility.

  3. List Sorting Working Memory Test

    Time frame: Baseline, 8 weeks, and 12 weeks.

    The raw score ranges from 0 to 24, with a higher score indicating better working memory. The raw score is converted to a Change Sensitive Score.

  4. Dimensional Change Card Sort Test

    Time frame: Baseline, 8 weeks, 12 weeks.

    The raw score ranges from 0 to 30, with a higher score indicating better executive function. The raw score is converted to a Change Sensitive Score.

  5. Flanker Inhibitory Control and Attention Test

    Time frame: Baseline, 8 weeks, and 12 weeks

    The raw score ranges from 0 to 30, with a higher score indicating better executive function and attention. The raw score is converted to a Change Sensitive Score.

  6. Pattern Comparison Processing Speed Test

    Time frame: Baseline, 8 weeks, and 12 weeks

    The raw score ranges from 0-133, with a higher score indicating better processing speed. The raw score is converted to a Change Sensitive Score.

  7. Speeded Matching Test

    Time frame: Baseline, 8 weeks, 12 weeks

    The score ranges from 0 to 130, with a higher score indicating better speed of processing. The raw score is converted to a Change Sensitive Score.

  8. Oral Symbol Digit Test

    Time frame: Baseline, 8 weeks, and 12 weeks

    The raw score ranges from 0 to 143, with a higher score indicating better processing speed. The raw score is converted to a Rasch score.

Other outcomes

  1. Patient Health Questionnaire-9

    Time frame: Baseline, 8 weeks, 12 weeks.

    The score ranges from 0 to 27, with a higher score indicating a higher degree of depression.

  2. Pain, Enjoyment of Life and General Activity Scale

    Time frame: Baseline, 8 weeks, and 12 weeks.

    The score ranges from 0 to 10, with a higher score indicating greater pain and interference with life by pain.

  3. Activity Measure for Post-Acute Care to measure everyday activity performance

    Time frame: Baseline, 8 weeks, and 12 weeks.

    The score ranges from 0 to 71, with a higher score indicating better mobility, daily activity function, or daily cognitive ability.

  4. Step counts

    Time frame: From enrollment to the end of intervention at 8 weeks.

    The number of step counts, a higher number indicates a higher level of physical activity.

  5. Sleep efficiently

    Time frame: From enrollment to the end of the intervention at 8 weeks.

    A ratio score of total sleep time divided by total time in bed per night, ranging from 0 to 1. A higher score indicates better sleep quality.

  6. Program satisfaction

    Time frame: 8 weeks

    A score ranges from 0 to 6, with a higher score indicating higher satisfaction.

Study contacts

Contact information is provided by the study sponsor or research team.

Chiung-ju Liu Associate Professor, PhD

CONTACT

[email protected]

352-273-6496

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Registry information

Official study title

Living Independence Through Functional Training (LIFT): Feasibility of Hybrid Task-Oriented Resistance Exercise Following Home Health Discharge

Acronym: LIFT

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 15, 2025
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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