University of Rochester Medical Center
Rochester, New York, 14642, United States
Location status: Recruiting
Recruiting
NCT Number: NCT05248581
Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
The goal of this study is to create a data registry to capture clinical, pathologic, and molecular data/outcomes for patients with metastatic colorectal cancer who undergo live donor liver transplantation.
Our primary outcome of interest was the OS and recurrence-free survival (RFS) of patients who underwent LDLT at our center.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age ≥ 18
- Non-amenable to curative hepatic resection as defined by FLR <30%
- Histologically confirmed adenocarcinoma of the colon or rectum
- Candidate for LDLT for colorectal liver metastasis per the University of Rochester liver transplant program
Exclusion criteria
- Not a candidate of the LDLT liver transplant protocol for treatment of colorectal liver metastasis.
- Unwilling to consent
Treatment and study plan
Liver Transplantation
Procedureliving donor liver transplantation
Primary outcomes
-
percentage of patients with recurrence free survival
Time frame: 5 years
RFS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis
-
percentage overall survival
Time frame: 5 years
OS proportions to be calculated at 1, 3, and 5 years with Kaplan Meier analysis
Study contacts
Contact information is provided by the study sponsor or research team.
Jennie Errigo
CONTACT
Roberto Hernandez-Alejandro, MD
CONTACT
Sponsors and collaborators
Lead sponsor
University of Rochester
Other
Registry information
Official study title
Liver Transplantation From Living Donors For Treatment Of Non-Resectable Colorectal Carcinoma Liver Metastases: A Registry Study
Important dates
- Study start
- 2019
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Feb 21, 2022
- Registry last updated
- Jul 20, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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