Liposomal Anthracyclin in the Treatment of Elderly ALL

Patients aged 55 years or over will be assessed for response to steroids from day -7 to day 0 During steroid therapy, Ph status will be determinated : patients with Ph+ ve ALL will be treated according to the another French Protocol while patients with Ph-ve ALL will be included in the "caelyx" protocol and randomly allocated to induction with VAD or with vadox-li-Peg (caelyx).

A second course of induction therapy with VAD+ cyclophosphamide of Vadox-li-peg+ cyclophosphamide(according to the initial randomization arm) will then be given to all patients.

Consolidation therapy included 2 courses of vad or of vadox-li-Peg , according to the initial random allocation, followed by two courses of cytarabine,cyclophosphamide and thioguanine.

During induction and consolidation therapy, doxorubicin and liposomal pegylated doxorubicin pharmacokinetics will be assessed in all patients.

Treatment of occult CNS invasion includes skull radiotherapy and 6 intrathecal injections(steroÏds+methotrexate) A two years maintenance course with 6 mercaptopurine and methotrexate will then be offered to all patients.

Inclusion criteria

• 55 years of age and older
• ECOG performance </=2 or >/=3
• VIH negative
• Absence of previous ALL treatment
• Informed consent signed
• SGPT and Bilirubin < 4x upper limit of normal
• Normal creatinine for age
• cardiac state compatible with anthacyclin

Exclusion criteria

• ALL with Philadelphia Chromosome
• ALL3
• CML blasts crisis
• Cardiac insufficiency and/ or left ventricular ejection fraction < 50%
• Evolutive infection
• Presence of other evolutifs cancer or ongoing treatment

• mental status incompatible with inform consent