Lip Reduction Surgery for Port-wine Macrocheilia

Patients with port-wine stains often develop macrocheilia, however, there is currently no effective treatment to significantly reduce the three-dimensional volume increase of the lips. This article presents a simplified "five-step" approach based on clinical experience, designed to assist inexperienced surgeons in performing this surgery effectively.

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Key information

Conditions

Port Wine Stains Hemangioma Hemangioma, Capillary Neoplasms Neoplasms by Histologic Type Neoplasms, Vascular Tissue

Age range

3 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine

Shanghai, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1. Patients with port-wine macrocheilia. 2. Patients that underwent lip reduction surgery. 3. Age at surgery: ≥3 years and ≤70 years.

Exclusion criteria

1. Patients without port-wine macrocheilia. 2. Missing/incomplete baseline patient information. 3. Patients without postoperative photographs.

Treatment and study plan

The Five-Step lip reduction surgery

Procedure

The Five-Step lip reduction surgery: (1) measurement and design; (2) incision and reduction of lip volume; (3) fixation and shape of the dry lip; (4) fixation and shape of the skin (the SMISS approach); (5) shaping of the wet lip mucosa (the SMISS approach).

Primary outcomes

the Visual Analog Scale

Time frame: From enrollment to the end of treatment in 6 months to one year

Sponsors and collaborators

Lead sponsor

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Other

Registry information

Official study title

Lip Reduction Surgery for Port-wine Macrocheilia: a Retrospective Single-center Clinical Study

Acronym: macrocheilia

Important dates

Study start: 2020
Primary completion: 2025
Study completion: 2025
First posted: Aug 19, 2025
Registry last updated: Aug 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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