Linking Obesity and Estrogen-responsive Genes in Endometrial Cancer

Inclusion criteria

• Age 18-80 years
• Any patient having abdominal surgery (Laparoscopic or open technique) for benign conditions
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Patients must have adequate:
• Hematologic function: Neutrophils ≥ 1.5 x 109/L and platelets ≥ 100 x 109/L
• Renal function: serum creatinine ≤ ULN or estimated glomerular filtration rate (eGFR) [CKD-EPI Formula] ≥ 60 mL/min
• Hepatic function: serum bilirubin ≤ 1.5 x ULN and AST ≤ 2.5 x ULN and ALT≤ 2.5 x ULN
• Physically able to undergo surgery
• Written informed consent

Exclusion criteria

• Confirmed gynaecological malignancy
• Contraindications and/or unfit for Surgery: serious concomitant systemic disorders incompatible with the study (at the discretion of the investigator);
• Patients who are pregnant or lactating
• Serious illness or medical condition but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia (patients with stable AF are eligible), or psychiatric illness/social situations that would limit compliance with study requirements.
• Patients with disseminated intra-peritoneal malignancy or suspected ovarian cancer
• HIV positive
• Previous bariatric surgery