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Completed

NCT Number: NCT07256314

Linking Dietary Nutrition, Dietary Patterns, Gut Microbiota, and Bone Density: A Cross-Sectional Study

The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the main factors affecting bone health from the perspective of nutrition and intestinal microecology, and to provide theoretical basis for the promotion and improvement of bone health in Tibetan primary school students.

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Key information

Conditions

Bone Density Gut Microbiomes

Age range

6 year–13 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Lanzhou university

Lanzhou, Gansu, 730000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Tibetan primary school students currently enrolled in schools in Gannan Tibetan Autonomous Prefecture;

Willing to participate and able to cooperate in completing bone density measurements;

Additional inclusion criteria: Subjects who are 9 years old or older and agree to participate in dietary surveys and fecal sampling.

Exclusion criteria

Use of corticosteroid medications within the past year;

Suffering from skeletal system diseases, metabolic disorders, or endocrine diseases;

Additional exclusion criteria: Subjects who have used antibiotics in the past three months and are undergoing fecal sampling.

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Treatment and study plan

No Intervention: Observational Cohort

Other

No Intervention

Primary outcomes

  1. Dietary Characteristics

    Time frame: Day 1

    Dietary data were collected using a food frequency questionnaire (FFQ) to analyze dietary patterns and nutrient intake.

  2. Bone density test

    Time frame: Day1

    In this study, a peripheral dual-energy X-ray absorptiometry (EXA-PRESTO) was used to measure the bone density of the non-dominant forearm of the subjects.

  3. Fecal sample microbiological testing and analysis

    Time frame: Day 1

    This study entrusted Tianhao Gene Technology Co., Ltd. to perform the intestinal microbiome Accu16STM (16S rRNA absolute quantitative sequencing). The main research processes include DNA extraction, PCR amplification, library construction, and sequencing.

Sponsors and collaborators

Lead sponsor

Jianhua Ma

Other

Registry information

Official study title

Investigating the Effects of Diet and Gut Microecology on Bone Health in Gannan Tibetan Elementary School Students

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Dec 1, 2025
Registry last updated
Dec 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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