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NCT Number: NCT07211321

Linking Diet, Inflammation, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study

Based on the analysis of dietary characteristics, gut microbiota diversity, and composition, this study investigates the relationships between the dietary inflammatory potential, gut microbiota, and sarcopenia. Furthermore, it explores the mediating role of gut microbiota in the association between the dietary inflammatory index and the risk of sarcopenia. The findings are expected to provide insights into the mechanisms through which dietary inflammation influences the development and progression of sarcopenia, and to offer a basis for dietary and nutritional interventions aimed at preventing or managing this condition.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Permanent residents of the community aged 60 years or older.
  • Continuous residence duration in the community for more than 5 years.

Exclusion criteria

  • Taking medications known to affect muscle function (e.g., corticosteroids, protein supplements, muscle enhancers).
  • Requiring walking assistance or having severe cognitive impairment that would preclude successful completion of assessments including bioelectrical impedance analysis (BIA), gait speed measurement, and handgrip strength testing.
  • Presence of a cardiac pacemaker, which contraindicates BIA measurement.
  • Diagnosis of one or more chronic diseases that significantly limit dietary intake.

Treatment and study plan

No Intervention: Observational Cohort

Other

No Intervention

Primary outcomes

  1. The prevalence of sarcopenia

    Time frame: Through study completion, an average of 1 year

    The diagnosis of sarcopenia is confirmed according to the AWGS 2019 criteria, which requires the assessment of muscle strength, physical performance, and muscle mass.

  2. Change in absolute abundance of Faecalibacterium prausnitzii

    Time frame: Through study completion, an average of 1 year

    16S rRNA absolute quantification was used to detect the microbial composition of the fecal samples.

  3. Dietary Characteristics

    Time frame: Through study completion, an average of 1 year

    Dietary data were collected using a food frequency questionnaire (FFQ) to analyze dietary patterns and nutrient intake.

Study contacts

Contact information is provided by the study sponsor or research team.

Jianhua Ma Doctor of Medicine

CONTACT

[email protected]

0086 18993157029

Sponsors and collaborators

Lead sponsor

Jianhua Ma

Other

Registry information

Official study title

Exploring the Relationship of Diets Inflammatory, Gut Microbiota, and Sarcopenia: A Cross-Sectional Study

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Oct 7, 2025
Registry last updated
Oct 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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