Limonene Study in Women With Breast Cancer

Inclusion criteria

• Women who are 18 years of age or older
• Women electing to undergo excision surgery for early stage breast cancer
• A minimum of 2 weeks from enrollment to definitive surgery
• Underwent core needle biopsy for breast cancer diagnosis
• No clinical evidence of metastatic breast cancer
• ECOG performance status 0-1
• Participants must have normal organ and marrow function
• Women of child-bearing potential must agree to use adequate contraception
• Ability to understand and the willingness to sign a written informed consent document

Exclusion criteria

• Concurrent chemotherapy or radiation therapy
• Use of selective estrogen receptor modifiers or aromatase inhibitors within the past 3 months or concurrently
• History of other malignancies within the past 5 years excluding non-melanoma skin cancer and cancers confined to organs with removal as only treatment
• Participated in another clinical intervention trial within the past 3 months
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant or breast-feeding women
• Use of dietary supplement that contains large amounts of d-limonene (such as Heartburn Free with ROH10 and CoQ with d-limonene) within the past 3 months