Skip to main content
OpenTrials
Completed

NCT Number: NCT03258190

Lime Powder Regimen (LPR) for Prevention of Renal Stone Recurrence

Lime powder regimen (LPR) is a lime-derived composition enriches with citrate/citric acid and potassium. LPR was invented to treat the renal stone patients with high risk of stone recurrence after stone removal. LPR should have equal or higher efficacy and lower adverse effect than current standard medicine.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Urolithiasis Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Urogenital Diseases Urologic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Chulalongkorn University

Bangkok, 10330, Thailand

About this study

Lime powder regimen (LPR) is a mixture of lime-derive component with adjuvants containing high concentration of citrate, and moderate amount of potassium, magnesium and antioxidants. LPR was tested and verified to be very less toxic in cell culture and animal models. The clinical trial phase II showed that LPR reduced urinary metabolic abnormalities that enhance stone formation, such as hypocitraturia, hypokaliuria and acidified urine. Adverse effect of LPR was very low.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Renal stone patients who were identified and stone was removed by surgical method.

Exclusion criteria

  • Chronic kidney disease, chronic liver disease, history of coronary artery disease, or person who takes any medication that alters urinary metabolic profiles

Treatment and study plan

Lime Powder Regimen

Drug

LPR and placebo were randomly given to subjects for 6 months

Other names: LPR supplement

Primary outcomes

  1. Renal stone recurrence

    Time frame: 6 months

    The stone recurrence after surgical removal of stone that can be detected by CT scan

Sponsors and collaborators

Lead sponsor

Chulalongkorn University

Other

Collaborators

  • Burapha University
  • Sanpasitthiprasong Hospital

Registry information

Official study title

Lime Powder Regimen Supplement Alleviates Urinary Metabolic Abnormalities to Prevent Urolithiasis Recurrence.

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Aug 23, 2017
Registry last updated
Feb 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.