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NCT Number: NCT07517484

Light and Anesthesia

The objective of this clinical trial is to investigate the effect of light exposure on sedation depth during general anesthesia.The primary research questions this study aims to address include:

Does light condition affect the dosage of anesthetic medications during anesthesia? By what mechanism does light exposure exert an influence on anesthesia? Participants will be randomly allocated to either the light-shielded group or the non-light-shielded group.Patients in the light-shielded group will wear an eye shield during anesthesia.

The following data will be recorded for all patients:

Induction drug dosage Induction time Intraoperative anesthetic dosage Emergence time

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Key information

Conditions

Light Anesthesia Sedation

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Peking University People's Hospital

Beijing, 100044, China

Location status: Recruiting

Location contact

Xiaoyan Li

CONTACT

[email protected]

18810599681

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a. Age between 18 and 65 years, regardless of gender;
  • b. ASA physical status I-II;
  • c. 18.5 ≤ BMI ≤ 28;
  • d. Signed written informed consent.

Exclusion criteria

  • a. Blindness or history of photosensitivity disorders;
  • b. Patients requiring medication for sleep, or with a history of sleep disorders;
  • c. Presence of neurological diseases;
  • d. Pregnancy;
  • e. Severe hepatic or renal dysfunction;
  • f. History of anesthetic drug abuse or alcohol abuse;
  • g. History of adverse anesthesia events (difficult airway, allergy to anesthetic agents).

Treatment and study plan

eye mask

Device

Patients in the light-shielded group will wear an opaque eye mask 30 minutes prior to induction of general anesthesia and continue to do so until the cessation of sedative medications for anesthesia.

Primary outcomes

  1. The dose of sedative medications

    Time frame: Perioperative

    The dose of sedative medications required during the induction period in patients

Secondary outcomes

  1. Induction time of anesthesia

    Time frame: Perioperative

    Induction time of anesthesia

  2. total dose of sedative medications

    Time frame: during surgery

    total dose of sedative medications required to maintain a certain range of anesthetic depth during surgery

  3. emergence time

    Time frame: Perioperative

    emergence time after drug discontinuation

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaoyan Li, Ph.D

CONTACT

[email protected]

18810599681

Yi Feng, Ph.D

CONTACT

[email protected]

010-88325590

Sponsors and collaborators

Lead sponsor

Peking University People's Hospital

Other

Registry information

Official study title

Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 8, 2026
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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