Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial

1-year change in the Lifestyle for BRAin Health (LIBRA) score 2. This is a weighted score of fifteen lifestyle-related risk factors that are proven to be associated with increased dementia risk. Higher score means a greater risk for dementia. Scored from -6.1 to 25.8 (absolute weight).

Measure of immediate and delayed memory. Wordlist is presented five times in a row and asked to be recalled immediately and after 15 minutes.

Discrete number; score: 0-15 (higher score means a better outcome)

Measure of attention/processing speed, number of correctly matched symbols to digits within 90 seconds.

Discrete number; 0-90 (higher score means a better outcome).

Measure of working memory. Scored as the maximum number of digits repeated correctly. Discrete number; 0-14 (higher score means a better outcome).

Measure of attention and executive function. Task A and B. Time taken to complete the test; minimum 0, no maximum, lower score means a better outcome.

Measure of language fluency. Semantic fluency test with category animals at baseline and professions at follow-up. Word count in one minute; minimum 0, no maximum, higher score means a better outcome.

Quality of life, score 0-100, higher scores indicate better quality of life

Capabilities, score 0-1, higher scores indicate greater capabilities.

3 subscales, where each subscale ranges from 6 (minimum score) to 36 (maximum score). Higher scores indicate higher health locus of control.

Total score ranges from 10 (minimum score) to 40 (maximum score), with higher scores representing higher self-efficacy.

Total score ranges from 7 (minimum score) to 28 (maximum score), where higher scores indicate greater levels of mastery.

Total, HDL, LDL and triglycerides in plasma (mmol/L).

Hemoglobin A1C (HbA1c) measured in plasma (%), indicates plasma glucose as a measure for diabetes status

Creatinine-based (as measured in plasma) estimated glomerular filtration rate (eGFR) (healthy level: higher than 60) indicating kidney function.

As calculated from weight (kg) and height (m), weight / height ^2

Scores range from approximately (for diastolic) 60-120 and (for systolic) 100-180 mmHg, with higher measures indicating higher blood pressure.

History of diabetes, coronary heart disease, kidney disease, hypertension, dyslipidemia, depression, hearing loss, poor vision, sleep disorders (asked in interview)

Total scores range approximately 20-70, higher scores indicate better ADL functioning.

Total score ranges from 0 (minimum score) to 14 (maximum score), with higher scores indicating higher adherence to Mediterranean diet.

Physical activity, uses Cambridge Physical Activity Index to categorize into 4 levels based on occupational and leisure-time activities.

The score ranges from 0 (minimum score) to 45 (maximum score), with higher scores representing higher cognitive and leisure activities.

Total score, scale 0 - 40, higher scores indicate more perceived stress.

Total score ranges from 0 (minimum score) to 27 (maximum score), with higher scores representing a worse outcome (more depressive symptoms).

The score ranges from 0 (minimum score) to 14 (maximum score), with higher scores representing a worse outcome (worse sleep quality)

The score ranges from 0 (minimum score) to 30 (maximum score), with higher scores meaning a better outcome (higher level of perceived social support)

The score ranges from 0 (minimum score) to 6 (maximum score), with higher scores representing a worse outcome (higher loneliness scores).

Measure awareness on risk and protective factors, higher score indicates better knowledge (0-25).

Duration (current/history) and quantity

Measured in duration (current/history) and quantity

Medical consumption, selection of specific questions on care use such as GP visits and dietician. Used to calculate overall costs of medical care to define the cost-effectiveness of the intervention. Lower costs is a better score.

Measures productivity costs, used to calculate cost-effectiveness of the intervention. Higher productivity and lower costs is a better score.

Appointments missed, personal goals reached in coaching sessions (number), vouchers used (number), usage log of breinzorg.nl self-management tool (time active, modules completed). Together, they will be used in a model to calculate cost-effectiveness of the intervention based on the adherence.

Plasma samples will be stored to later assess biomarkers. For example amyloid, p-tau, NFL, GFAP, BDNF.