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NCT Number: NCT02550236

LIFE Child (LIFE Leipzig Research Centre for Civilization Diseases)

The Leipzig Research Centre for Civilization Diseases (LIFE) Child Study is a prospective longitudinal population-based study with a life course approach to health and disease.

The LIFE Child Study focuses on two main research objectives:

* What are premises of normal growth, development and health in children? * Which factors contribute to the development of non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems?

Detailed assessments will be conducted alongside long-term storage of biological samples in 1,000 pregnant women and more than 5,000 children and their families.

Recruiting

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Key information

Conditions

Child Development

Age range

0 year–20 year

Sex eligibility

All sexes

Study type

Observational

Primary location

LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig

Leipzig, Saxony, 04103, Germany

Location status: Recruiting

Location contact

Antje Körner, Prof. MD

CONTACT

[email protected]

Antje Körner, Prof.,MD

PRINCIPAL_INVESTIGATOR

LIFE Child

CONTACT

[email protected]

About this study

  • The LIFE Child study is part of LIFE, a life sciences research program of the University of Leipzig (Leipzig Research Centre for Civilization Diseases - LIFE). The measurements are performed in a well-equipped research centre located on the premises of the University Hospital of Leipzig.
  • The study collects detailed information from clinical examinations, questionnaires and interviews and includes a collection of several types of biological materials at various time points (urine, stool, hair, blood for direct analyses, genomic DNA, dried blood spots, paxgenes (for RNA isolation and expression/eQTL studies). Children and adolescents from 0 to 20 years at baseline and their families are included. Participants are followed annually over a period of several years irrespective of the age at the first participation in the study until they reach the age of 20.
  • Prenatal examinations are conducted in the 24th and 36th week of gestation and postnatal examinations in the 3rd, 6th and 12th month in the offspring. The birth cohort study collects detailed information from clinical examinations, questionnaires and interviews and biological materials (blood, cord blood, placental tissue, breast milk, hair, urine and stool)
  • In addition, the LIFE Child study focuses in the disease cohort LIFE Child OBESITY and disease free controls in more detail. The aim of these subgroups is to examine aetiological associations and comorbidities with more in-depth methods.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • children with their families and pregnant women of the area of Leipzig

Exclusion criteria

  • severe diseases

Treatment and study plan

Primary outcomes

  1. Civilization diseases and their risk factors

    Time frame: 20 years

    Assess lifestyle, metabolic and genetic risk factors of civilization diseases (e.g. diabetes mellitus, obesity, allergy, cardiovascular diseases) from fetal life to adulthood.

Study contacts

Contact information is provided by the study sponsor or research team.

Antje Körner, Prof., MD

CONTACT

[email protected]

LIFE Child

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Leipzig

Other

Collaborators

  • European Regional Development Fund
  • European Social Fund
  • Free State of Saxony
  • Helmholtz Center for Environmental Research Leipzig
  • Leipzig Research Center for Early Child Development
  • Robert Koch Institute Berlin

Registry information

Official study title

Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases

Important dates

Study start
2010
Primary completion
2026
Study completion
2026
First posted
Sep 15, 2015
Registry last updated
Mar 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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