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NCT Number: NCT06107543

Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation.

In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively.

Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.

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Key information

Conditions

Lidocaine

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Derince Training and Research Hospital

Kocaeli, 41900, Turkey (Türkiye)

About this study

2% lidocaine drug to suppress the hemodynamic response due to laryngoscopy and endotracheal intubation; patients administered intravenously will be evaluated in one group, and patients administered inhaled through a nebulizer will be evaluated in another group.

Nebulized lidocaine in the researchers' clinic; it is administered by adding 2% lidocaine + physiological saline to a nebulizer and inhaling for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.

Preoperative examination forms and intraoperative follow-up forms of the patients included in the study will be examined by the researchers. The dose of lidocaine applied and the method of administration will be recorded. In addition, the agents used in anesthesia induction (fentanyl, propofol, rocuronium bromide, etc.) and the hemodynamic changes of the patients (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,oxygen saturation) will be recorded.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia

Exclusion criteria

  • Patients under the age of 18 and over the age of 80
  • Patients who are not operated under general anesthesia

Treatment and study plan

Nebulized Lidocaine

Drug

Before induction of anesthesia, 2% lidocaine + physiological saline was added to a nebulizer and inhaled for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.

IV Lidocaine

Drug

Intravenous %2 lidocaine was administered before induction of anesthesia.

Primary outcomes

  1. Heart Rate

    Time frame: Just before induction of anesthesia

    Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  2. Heart Rate

    Time frame: Immediately after induction of anesthesia

    Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  3. Heart Rate

    Time frame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

    Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)

  4. Blood Pressure

    Time frame: Just before induction of anesthesia

    The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  5. Blood Pressure

    Time frame: Immediately after induction of anesthesia

    The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  6. Blood Pressure

    Time frame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

    The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.

  7. Oxygen Saturation

    Time frame: Just before induction of anesthesia

    The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

  8. Oxygen Saturation

    Time frame: Immediately after induction of anesthesia

    The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

  9. Oxygen Saturation

    Time frame: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation

    The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.

Sponsors and collaborators

Lead sponsor

Derince Training and Research Hospital

Other

Registry information

Official study title

Retrospective Investigation of the Effects of Different Uses of Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 30, 2023
Registry last updated
Jun 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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