Lidocaine: Effect of Lidocaine in Chronic Cough

Inclusion criteria

• Male and female subjects, age 18 years and over.
• History of cough for more than 8 weeks.
• Normal chest x ray
• Chronic idiopathic cough or chronic cough resistant to treatment of specific triggers.

Exclusion criteria

• Smoking status:

• Current smokers
• Ex smokers with history of smoking > 20 pack years or those who have given up < 6 months ago.
• Prohibited medications:

• Use of medications likely to suppress / affect cough including codeine, morphine, pregabalin, gabapentin, amitriptylline, angiotensin converting enzyme inhibitors (type 1) and baclofen.
• Use of any anti-arrhythmic medication.
• Use of cimetidine, beta blockers, or diuretics.
• Cardiovascular conditions:

• Sinoatrial disease, bradycardia or all types of heart blocks.
• History of ischaemic heart disease or heart failure.
• Clinically significant abnormal electrocardiogram (ECG) at Screening or Baseline.
• History of cardiac surgery
• Respiratory conditions:

o Asthma.

• Central nervous system / Peripheral nervous system conditions:

• Epilepsy.
• Myasthenia gravis.
• Miscellaneous:

• History of hepatic or renal dysfunction.
• Porphyria
• History of hypersensitivity to Lidocaine or related drugs.
• Pregnancy or breast feeding.
• Participation in another trial within the preceding 6 weeks.
• Trauma or ulceration to oral mucosa.
• History of chest or upper airway infection within the past 6 weeks.
• Conditions which may affect cough response such as stroke, diabetes, Parkinson's Disease.