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Completed

NCT Number: NCT04322760

Lidocaine 5% Patch Supplementation to Intra-articular Bupivacaine Dexmedetomidine After Arthroscopic Knee Surgery

Surgery of the knee is a very common procedure which can be very painful and sufficient postoperative pain treatment is often problematic. The aim of this work was to study the effects of supplementation of intra-articular bupivacaine dexmedetomidine with lidocaine 5% patch after arthroscopic knee surgery under general anesthesia and its role in improving quality of anesthesia.

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Key information

Conditions

Dexmedetomidine Arthroscopic Knee Surgery Intra-articular Lidocaine 5% Patch

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients
  • ASA I & II
  • Aged between 18 to 60 years
  • Weight between 60 to 100 kg
  • Scheduled for elective arthroscopic knee surgery

Exclusion criteria

  • patient refusal.
  • history of cardiac disease.
  • impaired renal or hepatic function.
  • hypertension treated with α methyldopa, clonidine, or beta-adrenergic blockers.
  • if they have used opioid analgesics within the previous 24 hr.
  • previous sensitivity to local anesthetics.

Treatment and study plan

Lidocaine 5% patch with Dexmedetomidine Bupivacaine

Drug

10 ml 0.5 % Bupivacaine and 1µg/kg Dexmedetomidine diluted in 10 ml saline was injected intra-articularly through one of the arthroscopic ports after the end of the surgery under complete aseptic technique and a patch of lidocaine 5% was applied to the skin between the arthroscopic ports

dexmedetomidine bupivacaine

Drug

10 ml 0.5 % Bupivacaine and 1µg/kg Dexmedetomidine diluted in 10 ml saline was injected intra-articularly through one of the arthroscopic ports after the end of the surgery under complete aseptic technique without a patch of lidocaine 5%

Primary outcomes

  1. The total dose of postoperative pethidine consumption

    Time frame: 24 hours

    The total dose of postoperative pethidine consumption; Pethidine 20 mg was given as rescue analgesia if pain visual analogue visual analogue scale (VAS) ≥4.

Secondary outcomes

  1. First postoperative analgesia request time

    Time frame: 24 hours

    First postoperative analgesia (Pethidine 20 mg) request time

  2. Pain intensity

    Time frame: 24 hours

    Visual analogue scale (VAS) was recorded immediately postoperative and at 30 min, 1, 2, 4, 6, 12 and 24 hours postoperatively. The score ranges from 0 to 10; higher means worse pain

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

Effect of Lidocaine 5% Patch Supplementation to Intra-articular Bupivacaine Dexmedetomidine After Arthroscopic Knee Surgery Under General Anesthesia

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Mar 26, 2020
Registry last updated
Mar 27, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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