Recruiting

NCT Number: NCT07485621

LFP-based Parameter Prediction in DBS for Parkinson's Disease

The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. The main question it aims to answer is:

Aligns stimulation contact selection based on subcortical LFP recordings with clinically optimized contact selection?

Participants will undergo LFP recordings that are part of standard clinical care during their routine hospital visits.

Recruiting

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Key information

Conditions

Parkinson's Disease (PD) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospitals Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

Location status: Recruiting

Location contact

Bart Swinnen, MD, PhD

CONTACT

[email protected]

0031 16343044

Bart Swinnen, MD, PhD

PRINCIPAL_INVESTIGATOR

Loes Laurijssen, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Voluntary written informed consent of the participant
At least 18 years of age at the time of signing the Informed Consent Form (ICF)
Diagnosis of idiopathic Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society (MDS)
Eligible for DBS to treat refractory PD motor symptoms, as based on multidisciplinary DBS screening
Have sufficient understanding of the Dutch and French language to participate in the study

Exclusion criteria

Treatment and study plan

Primary outcomes

Alignment of contact selection

Time frame: From the first LFP recording to the last LFP recording (6 - 9 months)

Alignment between local field potential-based contact selection and the clinically optimized stimulation contact.

Study contacts

Contact information is provided by the study sponsor or research team.

Bart Swinnen, MD, PhD

CONTACT

[email protected]

0032 16343044

Sponsors and collaborators

Lead sponsor

Loes Laurijssen

Other

Registry information

Official study title

Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study

Important dates

Study start: 2026
Primary completion: 2029
Study completion: 2029
First posted: Mar 20, 2026
Registry last updated: Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting