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Completed

NCT Number: NCT03671408

Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients

Inflammation plays a key role in the deterioration of chronic heart transplants. Periodontal disease is not limited to the tooth-supporting structures - it also contributes to systemic inflammation. This study explored whether periodontitis is associated with serum high-sensitivity C-reactive protein (hs-CRP) levels in heart transplant patients.

The study included 33 patients who had undergone heart transplantation at Baskent University Hospital. Clinical periodontal parameters were recorded, and blood samples were collected on the same day to measure serum hs-CRP.

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Key information

Conditions

Heart Transplant Failure CRP Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

11 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

Of the 33 patients, 9 (27.3%) had periodontitis, 4 (12.1%) were periodontally healthy, and 20 (60.6%) had gingivitis. Serum hs-CRP was significantly higher in the periodontitis group than in the healthy and gingivitis groups (P = .006). hs-CRP also correlated positively with probing depth (r = 0.358; P = .041), clinical attachment level (r = 0.352; P = .045), and gingival recession (r = 0.422; P = .014).

Elevated hs-CRP in heart transplant patients was associated with periodontitis, supporting the value of regular periodontal visits after transplant.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who underwent heart transplant procedures at Baskent University Hospital

Treatment and study plan

clinical measurements

Other

only clinical parameters were recorded

Other names: no intervention was made

Primary outcomes

  1. hs-CRP levels

    Time frame: Day 1

    Serum hs-CRP levels were compared between the groups (periodontitis vs. periodontally healthy vs. gingivitis)

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Official study title

Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients With and Without Periodontitis

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Sep 14, 2018
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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