Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age

Inclusion criteria

• Male, 65-75 years of age
• BMI 18-28 kg/m2
• Non smoker
• Not performing regular resistance type exercise
• Participant is willing and able to give informed consent for participation in the study

Exclusion criteria

• A BMI <18 or >28 kg·m-2
• Active cardiovascular disease: uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
• Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
• Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)
• Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)
• Active inflammatory bowel disease
• Acute infection
• Acute or chronic renal disease
• Malignancy (or history of malignancy with 5 y)
• Recent steroid treatment (within 6 mo), or hormone replacement therapy
• Coagulopathy
• Musculoskeletal or neurological disorders
• Known allergies to any of the product ingredients
• Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance