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Completed

NCT Number: NCT01192009

Leucine Supplementation and Skeletal Muscle Disuse

Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.

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Key information

Conditions

Disuse Atrophy Atrophy Muscular Diseases Muscular Disorders, Atrophic Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of São Paulo - School of Physical Education and Sports

São Paulo, 05508-030, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of anterior cruciate ligament injury
  • Physically active
  • Must be able to swallow tablets
  • Non-smokers
  • Do not use nutritional supplements

Exclusion criteria

  • Post-surgical complications

Treatment and study plan

Leucine

Dietary Supplement

7.2 g of leucine during 2 weeks

Placebo

Dietary Supplement

7.2 g of alanine during 2 weeks

Primary outcomes

  1. Skeletal muscle structure (cross-sectional area)

    Time frame: 2 weeks

Secondary outcomes

  1. Molecular signalling pathways (hypertrophy, atrophy, and inflammation)

    Time frame: 2 weeks

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Leucine and Skeletal Muscle Disuse: Clinical Anti-Atrophic Effectiveness and Related Mechanisms

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Aug 31, 2010
Registry last updated
Feb 25, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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