Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast Cancer

OBJECTIVES:

Primary

• To evaluate verbal episodic memory in patients with breast cancer after 6 months of treatment with aromatase inhibitors (AI) vs tamoxifen citrate.

Secondary

• To evaluate cognitive functions of these patients at month 6 and 12 of treatment.
• To evaluate the psychological and social impact on these patients at month 6 and 12 of treatment.

OUTLINE: This is a multicenter study.

Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive oral tamoxifen citrate once daily for 1 year in the absence of disease progression or unacceptable toxicity.
• Arm II: Patients receive an oral aromatase inhibitor (letrozole, anastrozole, or exemestane) once daily for 1 year in the absence of disease progression or unacceptable toxicity.

Patients undergo cognitive, psychological, social, and quality of life assessments every 6 months using the CDS scale, the Edinburgh Handedness Inventory, the Mini Mental Test, the French version of the National Adult Reading Test, the Benton Visual Retention test, the direct and indirect capacities of the WAIS-R, the WMS sequential visual-spatial capacity, the dual task test, categorical and formal verbal fluency, the Trail making test, the Stroop test, the Wisconsin Card Sorting test, the choice reaction time test, the sequential visual spatial capacity, the HADS scale, IADL, and QLQ-C30 questionnaires.

After completion of study treatment, patients are followed for 1 year.

DISEASE CHARACTERISTICS:

• Histologically confirmed breast cancer
• No metastatic disease
• Meets criteria for initiating adjuvant endocrine therapy
• Hormone receptor status:

• Estrogen receptor- and/or progesterone receptor-positive disease

PATIENT CHARACTERISTICS:

• Postmenopausal, defined as no menstruation for ≥ 1 year, confirmed by a measurement of FSH and 17-beta-estradiol
• Karnofsky performance status 80-100%
• Native speaker of French
• Beneficiary of a French Social Security insurance plan
• No prior cognitive disorders
• No depression or other confirmed active psychiatric disease
• Able to undergo the medical monitoring of the trial due to geographic, social or psychological reasons
• No personal or family history of thromboembolic disease

PRIOR CONCURRENT THERAPY:

• No prior adjuvant chemotherapy
• No concurrent follow-up participation on another study
• No concurrent treatment with psychotropic substances (i.e., long half life benzodiazepines, antipsychotics, anticholinesterase)