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Completed

NCT Number: NCT02174146

Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?

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Key information

Conditions

Chronic Periodontitis Chronic Disease Diabetes Mellitus Diabetes Mellitus, Type 2 Disease Attributes Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Mouth Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases Type 2 Diabetes Mellitus

Age range

35 year–54 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of oral and dental medicine

Cairo, Egypt

About this study

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diabetic patients having diabetes mellitus ≥5 years prior to the study.
  • chronic periodontitis with clinical attachment loss > 5 mm.
  • otherwise systemically healthy subjects.

Exclusion criteria

  • any known systemic diseases other than diabetes.
  • pregnancy or lactation.
  • smokers.
  • receiving periodontal treatment in the last 6 months.
  • taking any drugs or medications other than anti-diabetic drugs.

Treatment and study plan

Non-surgical periodontal therapy

Procedure

supra and subgingival debridement

Other names: scaling and root planing

Primary outcomes

  1. visfatin levels in gingival tissues

    Time frame: 3 months

    estimation of protein and gene expression of visfatin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

  2. leptin levels in gingival tissue

    Time frame: 3 months

    estimation of protein and gene expression of leptin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

Secondary outcomes

  1. pocket depth

    Time frame: 3 months

    estimation of pocket depth in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

  2. clinical attachment level

    Time frame: 3 months

    estimation of clinical attachment level in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Non-surgical Periodontal Therapy on Leptin and Visfatin Expression in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Utilizing ELISA and Real Time PCR

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jun 25, 2014
Registry last updated
Jun 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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