Leptin and Ghrelin in ICU

Enteral alimentation is the preferred modality of support in critical patients who have acceptable digestive function and are unable to eat orally, but the advantages of continuous versus intermittent administration are surrounded by controversy.

This prospective, randomised study was designed to compare two enteral feeding methods with respect to changes in levels of leptin and ghrelin in ICU.

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Key information

Conditions

Critically Ill Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital

Altinordu, Ordu, 52100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

who were unable to ingest an oral diet
given decision on enteral feeding

Exclusion criteria

Carcinomatosis
irreversible coma
death or discharge before 14 days of observation
contraindication to enteral feeding
intolerance to the prescribed nutrients or infusion regimen
burn
multiple trauma
morbid obesity
end stage liver or renal or lung disease
severe sepsis or septic shock
patients with percutaneous endoscopic gastrostomy
immunosuppressive drug use
severe hemodynamic instability
massive blood transfusion

Treatment and study plan

enteral feeding by nasogastric tube.

Other

method of administration enteral feeding by nasogastric tube.

Primary outcomes

Change from baseline in serum leptin concentration at three weeks in ICU

Time frame: first, 7th, 14th and 21th day
Change from baseline in serum ghrelin concentration at three weeks in ICU

Time frame: first, 7th, 14th and 21th day in ICU

Sponsors and collaborators

Lead sponsor

özgür yağan

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2016
First posted: Nov 4, 2014
Registry last updated: Mar 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed