Legionnaires' Effect on Smell

The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants. Such testing will require approximately 20-30 minutes of the participant's time. The participants will take the University of Pennsylvania Smell Identification Test (UPSIT), a scratch-and-sniff test to assess their ability to identify odors in a forced- choice format. Volunteers will also complete a questionnaire asking personal history, demographic questions, and medical history.

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Key information

Conditions

Legionnaires' Disease Bacterial Infections Bacterial Infections and Mycoses Gram-Negative Bacterial Infections Infections Legionellosis Respiratory Tract Diseases Respiratory Tract Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Persons of generally good health, as obtained from a screening questionnaire who are 18 years of age and older
Both men and women of all ethnic backgrounds will be accepted.

Exclusion criteria

Age less than 18
Pregnant Women
Persons who mental competence is limited, such as those with dementia

Treatment and study plan

The University of Pennsylvania Smell Identification Test (UPSIT)

Other

This standardized test, the most widely used olfactory test in the world, is derived from basic psychological test measurement theory and focuses on the comparative ability of subjects to identify odorants at the suprathreshold level. The UPSIT consists of four envelope-sized booklets, each containing ten "scratch and sniff" odorants embedded in 10- 50-µm polymer microcapsules positioned on brown strips at the bottom of the pages of the booklets.

Primary outcomes

Score on the University of Pennsylvania Smell Identification Test

Time frame: 20-30 Minutes

The number of correct odor identification responses out of 40 from the standardized University of Pennsylvania Smell Identification Test.

The total number of correct responses will then be compared to standard norms of correct responses based on demographic information such as age and sex. Comparing the scores to the standard norms collected will indicate whether a volunteer is normosmic, hyposmic, or anosmic.

Secondary outcomes

Questionnaire Responses

Time frame: 20-30 Minutes

These are various demographic and medical history questions regarding exposure to Legionella Pneumonia and current experiences post diagnosis and treatment.

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Registry information

Official study title

Legionella Pneumonia's Effect on Olfactory Function

Important dates

Study start: 2017
Primary completion: 2024
Study completion: 2024
First posted: Oct 26, 2017
Registry last updated: Jul 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed